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1xbet best casino website Description:1xbet best casino website Spectrometer, Varian 500 MHz Unity Plus

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The mission of Biomolecular 1xbet best casino website facility is to assist K-State life science researchers interested in (1) characterizing protein domain constructs of novel biologically-important gene products, (2) developing robust and general methods for high-level expression and isotopic (15N, 13C and 2D ) enrichment of these domains for 1xbet best casino website studies, (3) applying multi-dimensional 1xbet best casino website methodology for determining 3D structure of these domains and in studying binding of inhibitor on protein molecules, and (4) identifying the small molecular weight metabolites by means of 1xbet best casino website spectroscopy. The goal of the Functional Genomics Consortium, funded by the K-State Targeted Excellence Program, is to facilitate utilization of functional genomics strategies aimed at both small and large biological problems, and, in particular, to enhance the ability of investigators to analyze gene function at the protein and metabolite levels. To this end, a research associate at the facility will be available to interact extensively with users, providing support and education.

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Capabilities

The facility contains more than ,000,000.00 in research equipment including a ?state-of-the-art? 500 MHz Varian 1xbet best casino website Superconducting Spectrometer System equipped with pulsed field gradient accessory, a four channel detection system, two waveform generators, a 5mm latest generation carbon enhanced Cold Probe, a 3 mm [1H/13C/15N/31P] Penta probe, a 5mm [1H/13C/15N] triple resonance and indirect detection probe and a 5 mm [15N-31P] broadband probe with high stability temperature controller for multinuclear/multi-dimensional 1xbet best casino website experiments. Five Linux workstation with XPLOR/CNS modeling programs and processing software are available for off-line 1xbet best casino website data processing and storage, and 3D structure calculations.

Importance

This spectroscopy is still the only method of determining 3-D solution structure of proteins and other macromolecules at the atomic level. An 1xbet best casino website study provides information that is sometimes unique and hard to obtain with other techniques. The dynamic phenomena, responsible for understanding how proteins achieve their unique function; can be studied by 1xbet best casino website spectroscopy.

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1xbet best casino website spectroscopy uses the magnetic property, called spin, of a nucleus in an atom. When a sample is set in a strong magnetic field, it is possible to transfer energy into the spin system in the form of radio frequency pulses and this changes the energy level of the spins. After the pulse the spin system relaxes back to its equilibrium state, sending a weak signal that can be recorded. The 3D structure of molecules can be obtained from these individual signals.

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•3D solution structures and dynamics of 1xbet best casino website , peptides and other biomolecules.
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In summary this facility is capable to solve structural and dynamics problems in molecular pharmacology, rational drug designing, 1xbet best casino website folding and solution phase biostructure. Training, education and consultation for users are also provided.

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1xbet best casino website Description

Our laboratory uses state-of-the-art multidimensional 1xbet best casino website spectroscopy along with computer aided molecular modeling to solve structural and dynamics problems in molecular pharmacology, rational drug designing, protein folding and solution phase biostructure. We are interested in utilizing structure of peptides, proteins, enzymes, receptors and acceptors as templates in drug designing. We are also interested in developing programs and routines for computer aided structure and conformation elucidation. Once an accurate model is determined, we use it as a template for design of appropriate constrained peptide ligands. In summary, the integration of above mentioned knowledge such as structure-function and molecular recognition may play a key role for the successful design of pharmaceuticals in the future. Furthermore, these studies can guide the design of future experiments, particularly that employing recombinant DNA technology to create new protein structures useful in developing resistance to insects and diseases in plants and animals.

1xbet best casino website Spectrometer, Varian System 500 MHz with Cold Probe

The Varian System 500 MHz nuclear magnetic resonance (1xbet best casino website ) spectrometer with Cold Probe is located in the 1xbet best casino website Facility (Chalmers Hall). The console is equipped with four radio frequency channels and a Z-axis gradient amplifier and is controlled by a Linux computer connected to the network. Researchers use this system to perform solution-state 1xbet best casino website experiments and metabolomic studies.