April 18, 2024
Hillary McGraw to present Division of Biology Seminar
Submitted by Division of Biology
Hillary McGraw, assistant professor in the Division of Biological and Biomedical Systems at the 1xbet online sports betting of Missouri-Kansas City, will present "Wnt Signaling Regulates Cellular Development and Regeneration in the Zebrafish Lateral Line" as part of the Division of Biology Seminar Series at 3:30 p.m. Monday, April 22, in Room 221 of Ackert Hall.
The zebrafish lateral line system has proven to be an invaluable model for the study of mechanosensory hair cell biology. The morphological and genetic profiles of lateral line hair 1xbet online sports betting are strikingly similar to the mechanosensory hair 1xbet online sports betting of the auditory and vestibular systems in the inner ear, with the advantage of being easily accessible to analysis and manipulation.
In addition, lateral line hair 1xbet online sports betting in the zebrafish possess a robust ability to regenerate throughout the lifespan of the animal, which contrasts with the lack of regeneration seen in the mammalian inner ear. The lateral line system is composed of sensory organs, called neuromasts, that contain mechanosensory hair 1xbet online sports betting and surrounding populations of support 1xbet online sports betting , which proliferate and differentiate to replace damaged 1xbet online sports betting .
Canonical Wnt signaling has been shown to be a core pathway in regulating zebrafish posterior lateral line regeneration. To elucidate the precise role of Wnt signaling,McGraw's team used mutant zebrafish strains which alter the Wnt pathway. Two of these lines alter Wnt signaling in opposing directions; krm1nl10 results in overactive Wnt signaling and lef1nl2 results in reduction of Wnt signaling. In the krm1nl10 mutants, the team found that development of support 1xbet online sports betting is significantly increased in lateral line neuromasts and that this increase in support 1xbet online sports betting results in supernumerary hair cell development and regeneration. The team found that this excess regeneration occurs in the absence of increased proliferation, in contrast to the previously described role of Wnt signaling in the lateral line. This work will allow us to understand the biology of mechanosensory hair 1xbet online sports betting , and how regeneration might be promoted following damage. This research is supported by NIGMS 1R16GM146690-01.
If you would like to visit with McGraw, please contact Jocelyn McDonald at jmcdona@k-state.edu.