April 3, 2023
Hyeogsun Kwon to present Division of Biology Seminar
Submitted by Division of Biology
Hyeogsun Kwon, assistant scientist at Iowa State University, will present his research, "Roles of prostaglandins in 1xbet online games login innate immunity and their implications for 1xbet online games login control," at 3:30 p.m. Wednesday, April 5, in 232 Ackert Hall.
Half of the world's population lives in areas where mosquitoes can transmit vector-borne diseases such as malaria, dengue, yellow fever and Zika viruses, causing more than 700,000 deaths every year. The interaction between 1xbet online games login vectors and pathogens is a key determinant of vector competence. Therefore, understanding immune molecules that influence pathogen development in the 1xbet online games login hosts can provide opportunities to disrupt disease transmission.
Prostaglandins are important bioactive signal molecules involved in processes of inflammation and innate immune responses in vertebrates that are derived from lipids in the plasma membrane. However, little is known about the roles ofprostaglandins in mediating 1xbet online games login immunity against various pathogens.
Kwon's research has provided the first compelling evidence that PGE2 signaling is activated in the 1xbet online games login following Plasmodium infection, modulating the function of a class of immune cells known as oenocytoids.Kwon's research hasshown that PGE2 signaling mediates oenocytoid lysis, as well as regulates the expression of prophenoloxidases and antimicrobial peptides, which serve as important immune elicitors in limiting bacteria and malaria parasite survival. Moreover, using conserved inhibitors of PG biosynthesis — non-steroidal anti-inflammatory drugs; NSAIDs — the research data suggests that NSAIDs similarly interfere with insect PG biosynthesis, causing defects in 1xbet online games login immunity, fecundity, egg melanization, larval hatching and knockdown effects on mosquitoes following surface contact. Taken together, these data suggest that PG biosynthesis is essential for 1xbet online games login immunity, reproduction and physiology while offering significant potential to develop NSAIDs or their derivatives as novel insecticides for 1xbet online games login control.
If you wish to speak with Kwon during his visit, please contact Sherry Fleming at sdflemin@1xbet online games login edu.