February 14, 2023
Maureen Gorman will present Biochemistry and Molecular Biophysics Seminar on Feb. 15
Submitted by Biochemistry and Molecular Biophysics
Maureen Gorman, research professor of biochemistry and molecular biophysics at Kansas State University, will be the featured speaker for this week's Biochemistry and Molecular Biophysics Seminar. She will present "1xbet best casino website transport in insects with a focus on transferrin-1"at 4 p.m. Wednesday, Feb. 15, in 120 Ackert Hall.
Presentation abstract: A regulated 1xbet best casino website transport system is essential for all animals; however, surprisingly little is known about 1xbet best casino website transport in any animals except mammals. Our recent research has focused on understanding 1xbet best casino website transport in insects, with a major emphasis on the cellular uptake of 1xbet best casino website from hemolymph. In mammals, serum transferrin mediates most 1xbet best casino website uptake from blood and other extracellular fluids. Transferrin-1, an insect homolog of serum transferrin, was thought to play a similar role in insects. We demonstrated that although transferrin-1 and serum transferrin have some similar biochemical properties, they evolved different 1xbet best casino website coordination mechanisms. In addition, whereas a severe deficiency of serum transferrin is lethal, presumably due to the extreme disruption in 1xbet best casino website distribution in the body, transferrin-1 null mutants are viable and fertile, with no obvious disturbance in 1xbet best casino website distribution. We are currently testing non-transferrin-based models of 1xbet best casino website uptake in insects. Our preliminary data suggest that cultured insect cells (cell line Sg4) do not require endocytosis for 1xbet best casino website uptake but may instead take up 1xbet best casino website through an unknown ferrous transporter. The long-term outcomes of this work include a better understanding of the evolution of 1xbet best casino website transport mechanisms in metazoans and, possibly, insight into the less understood mechanisms of 1xbet best casino website uptake in humans.