1xbet online casino 7, 2019
David Bedwell presents Division of Biology Seminar 1xbet online casino 8
Submitted by 1xbet online casino Biology
David Bedwell, professor at the University of Alabama at Birmingham, will present "Suppression of Nonsense Mutations to Treat Genetic Diseases" as part of the Division of Biology Seminar Seriesat 4 p.m. Friday,1xbet online casino 8, in 221 Ackert Hall.
Bedwellwill talk on11 percent of all disease-causing mutations that are nonsense mutations, which generate in-frame premature termination codons, or PTCs, in the mRNA. A PTC reduces protein expression by: terminating translation before a full-length protein is made; and destabilizing the mRNA by activating nonsense-mediated mRNA decay, or NMD, a pathway that recognizes and degrades PTC-containing mRNAs. It follows that translation termination and NMD represent potential therapeutic targets for drug discovery to treat diseases caused by PTCs. By modulating one or both of these pathways to suppress the effects of PTCs, 1xbet online casino hypothesizes that protein function can be directly restored for many genetic diseases. This seminar will discuss how translation termination works and provide his current progress in developing small molecules that suppress PTCs to treat various genetic disorders.
If you would like to visit with 1xbet online casino , contact Luke Messer at clukemesser@k-state.edu.