Amanda Higley, ph 1xbet online games login.D. (2009)
Major Professor:
Dr. Stephen Kiefer
Title and Institution:
Research Psychologist, University of California San Diego/VA Health Services
Dissertation:
Evidence for the role of the dopamine D3 receptor in mediating 1xbet online games login addiction
Abstract:
1xbet online games login is a potent psychomotor stimulant and a major drug of abuse. There is currently no effective medication available for treatment for 1xbet online games login addiction. The present study investigated the role of the dopamine D3 receptor on IV 1xbet online games login self-administration and its effect on 1xbet online games login induced neurochemical changes. Acute administration of the putative D3 receptor antagonists PG-01037 (10, 30 mg/kg, ip) and SB-277011A (12, 24, mg/kg, ip) significantly decreased the break-point for 1xbet online games login self-administration under a progressive-ratio (PR) schedule by 45 - 70%. Furthermore, both drugs dose dependently attenuated 1xbet online games login -triggered reinstatement of drug-seeking behavior in the reinstatement model of relapse. As with other drugs of abuse, the rewarding effects of 1xbet online games login are believed to be mediated by elevated levels of extracellular dopamine in the mesocorticolimbic system. The present study utilized in vivo microdialysis to examine the neurochemical mechanisms modulating the rewarding effects of 1xbet online games login actions evident in the various animal models of addiction. In the nucleus accumbens and ventral pallidum, acute 1xbet online games login (1.0 mg/kg, i.p.,) increased extracellular dopamine by 800 - 900% and decreased GABA by 60 - 65 % in the nucleus accumbens and ventral pallidum. Pretreatment with SB-277011A (12, 24 mg/kg) potentiated the 1xbet online games login induced dopamine increase but attenuated the 1xbet online games login -induced GABA decrease. Take together these data suggest that D 3 selective antagonists' pharmacotherapeutic potential in the treatment of 1xbet online games login addiction may involve a GABAergic mechanism.