margaret 1xbet online casino Gill, Ph.D.

COMPANY: Medical University of South Carolina in the Department of Neuroscience

Advisor: Dr. Mary Cain

Dissertation Title

The role of mGluR5 during conditioned hyperactivity and 1xbet online casino in differentially reared rats.

Dissertation Abstract

Glutamate contributes to the changes that occur during differential rearing, and those that occur during conditioned hyperactivity and 1xbet online casino . Metabotropic glutamate receptor 5 (mGluR5) in particular contributes to the psychostimulant reward pathway, plasticity, and differential rearing. The present study examined the role of mGluR5 in conditioning and 1xbet online casino in differentially reared rats. Rats were reared in an enriched (EC), impoverished (IC), or social (SC) condition for 30 days, after which they received repeated amphetamine (0.3 mg/kg) or saline injections. Following training, rats received an injection of the mGluR5 antagonist MTEP or saline prior to undergoing conditioned hyperactivity and 1xbet online casino tests. Results showed that MTEP attenuated conditioned hyperactivity and 1xbet online casino in IC but not EC and SC rats, suggesting that glutamatergic changes occur during differential rearing that alter the effects of MTEP on amphetamine conditioning and 1xbet online casino . Additionally, results demonstrated that enrichment rearing has a protective effect against conditioned hyperactivity at low doses of amphetamine.

Education

Ph.D., Psychology, Kansas State University, 2010