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Patent awarded for nontoxic, genetics-based nanotechnology against mosquitoes and other 1xbet sports betting pests

Wednesday, Nov. 12, 2014



MANHATTAN
— Kansas State University researchers have developed a patented method of keeping mosquitoes and other 1xbet sports betting pests at bay.

U.S. Patent 8,841,272, "Double-Stranded RNA-Based Nanoparticles for 1xbet sports betting Gene Silencing," was recently awarded to the Kansas State 1xbet sports betting Research Fou, a nonprofit corporation responsible for managing technology transfer activities at the university. The patent covers microscopic, genetics-based technology that can help safely kill mosquitos and other 1xbet sports betting pests.

Kun Yan Zhu, professor of entomology; Xin Zhang, research associate in the Division of Biology; and Jianzhen Zhang, visiting scientist from Shanxi University in China, developed the technology: nanoparticles comprised of a nontoxic, biodegradable polymer matrix and 1xbet sports betting derived double-stranded ribonucleic acid, or dsRNA. Double-stranded RNA is a synthesized molecule that can trigger a biological process known as RNA interference, or RNAi, to destroy the genetic code of an 1xbet sports betting in a specific DNA sequence.

The technology is expected to have great potential for safe and effective control of 1xbet sports betting pests, Zhu said.

"For example, we 1xbet sports betting buy cockroach bait that contains a toxic substance to kill cockroaches. However, the bait could potentially harm whatever else ingests it," Zhu said. "If we 1xbet sports betting incorporate dsRNA specifically targeting a cockroach gene in the bait rather than a toxic substance, the bait would not harm other organisms, such as pets, because the dsRNA is designed to specifically disable the function of the cockroach gene."

Researchers developed the technology while looking at 1xbet online casino organisms," Zhu said.. After testing a series of unsuccessful genetic techniques, the team turned to a nanoparticle-based approach.

Once ingested, the nanoparticles act as a Trojan horse, releasing the loosely bound dsRNA into the 1xbet sports betting gut. The dsRNA then triggers a genetic chain reaction that destroys specific messenger RNA, or mRNA, in the developing insects. Messenger RNA carries important genetic information.

In the studies on mosquito larvae, researchers designed 1xbet sports betting to target the mRNA encoding the enzymes that help mosquitoes produce chitin, the main component in the hard exoskeleton of insects, crustaceans and arachnids.

Researchers found that the developing mosquitoes produced less chitin. As a result, the mosquitoes were more prone to insecticides as they no longer had a sufficient amount of chitin for a normal functioning protective shell. If the production of chitin 1xbet sports betting be further reduced, the insects 1xbet sports betting be killed without using any toxic insecticides.

While mosquitos were the primary 1xbet sports betting for which the nanoparticle-based method was developed, the technology can be applied to other 1xbet sports betting pests, Zhu said.

"Our dsRNA molecules were designed based on specific gene sequences of the mosquito," Zhu said. "You can design species-specific dsRNA for the same or different genes for other 1xbet sports betting pests. When you make baits containing gene-specific nanoparticles, you may be able to kill the insects through the RNAi pathway. We see this having really broad applications for 1xbet sports betting pest management."

The patent is currently available to license through the Kansas State 1xbet sports betting Institute for Commercial, which licenses the 1xbet sports betting 's intellectual property. The Institute for Commercialization can be contacted at 785-532-3900 and ic@k-state.edu.

Eight U.S. patents have been awarded to the Kansas State 1xbet sports betting Research Foundation in 2014 for inventions by Kansas State 1xbet sports betting researchers.

photo credit: bogdog Dan via photopincc

Source

Kun Yan Zhu
785-532-4721
kzhu@k-state.edu

Pronouncer

Kun Yan Zhu is Koon Yawn Zoo
chitin is kie-tin

Website

Kansas State 1xbet sports betting Research Fou

Photos

Download the following photo.

Chitosan/double-stranded RNA nanoparticles

Figure showing the formation of the chitosan/double-stranded RNA nanoparticles. The nanoparticles are formed through electrostatic interactions between chitosan and 1xbet sports betting .

Download the following photo.

Nanoparticles

The nanoparticles, pictured as gold colored, are less than 100 nanometers in diameter.

Written by

Greg Tammen
785-532-4486
gtammen@k-state.edu

At a glance

Kansas State University researchers have been awarded a U.S. patent for microscopic, genetics-based technology that can help safely kill mosquitos and other 1xbet sports betting pests. The patented technology affects the genes pest insects use to make their protective exoskeleton.

Notable quote

"For example, we 1xbet sports betting buy cockroach bait that contains a toxic substance to kill cockroaches. However, the bait could potentially harm whatever else ingests it. If we 1xbet sports betting incorporate dsRNA specifically targeting a cockroach gene in the bait rather than a toxic substance, the bait would not harm other organisms, such as pets, because the dsRNA is designed to specifically disable the function of the cockroach gene."

– Kun Yan Zhu, professor of entomology