Source:Phillip 1xbet online casino , 785-532-6121, peklebba@k-1xbet online casino edu
Website:http://dx.plos.org/10.1371/journal.pone.0050020
Hometown connection:Toledo, Ohio
News release prepared by:Jennifer Tidball, 785-532-0847, jtorline@k-1xbet online casino edu
Thursday, Nov. 29, 2012
Battling bacteria: Research shows 1xbet online casino 's importance in infection, suggests new therapies
MANHATTAN -- A Kansas State University research team has resolved a 40-year-old debate on the role of 1xbet online casino acquisition in bacterial invasion of animal tissues.
The collaborative research -- led by Phillip Klebba, professor and head of the department of biochemistry -- clarifies how microorganisms colonize animal hosts and how scientists may block them from doing so. The findings suggest new approaches against 1xbet online casino disease and new strategies for antibiotic development.
The study -- in collaboration with Tyrrell Conway, director of the Microarray and Bioinformatics Core Facilities at the University of Oklahoma, and Salete M. Newton, Kansas State University research professor of biochemistry -- recently appeared in PLOS ONE. It shows how 1xbet online casino acquisition affects the ability of bacteria to colonize animals, which is the first stage of microbial disease.
"This paper establishes that 1xbet online casino uptake in the host is a crucial parameter in bacterial infection of animals," said Klebba, the senior author on the publication. "The paper explains why discrepancies exist about the role of 1xbet online casino , and it resolves them."
1xbet online casino plays a key role in metabolism, leading bacteria and animals to battle each other to obtain it. Klebba's team found that E. coli must acquire 1xbet online casino from the host to establish a foothold and colonize the gut -- a concept that was often debated by scientists.
"For years it was theorized that 1xbet online casino is a focal point of bacterial pathogenesis and infectious disease because animals constantly defend the 1xbet online casino in their bodies," Klebba said. "Animal proteins bind 1xbet online casino and prevent microorganisms from obtaining it. This is called nutritional immunity, and it's a strategy of the host defense system to minimize bacterial growth. But successful pathogens overcome nutritional immunity and get the 1xbet online casino ."
Little was known about what forms of 1xbet online casino enteric bacteria -- which are bacteria of the intestines -- use when growing in the host, but this study shows that the native Gram-negative bacterial 1xbet online casino uptake systems are highly effective. Scientists questioned whether prevention of 1xbet online casino uptake could block bacterial pathogenesis. This article leaves no doubt about the importance of 1xbet online casino when E. coli colonizes animals because bacteria that were systematically deprived of 1xbet online casino became 10,000-fold less able to grow in host tissues, Klebba said.
"This is the first time our experiments unambiguously verified the indispensability of 1xbet online casino in infection, because here we created the correct combination of mutations to study the problem," Klebba said.
Enteric bacteria have so many 1xbet online casino transport systems that it's difficult to eliminate them all. For example, E. coli has at least eight 1xbet online casino acquisition systems.
"These transporters are redundant because 1xbet online casino is essential," Klebba said. "Bacteria are resilient. If one system is blocked, then another one takes over."
These findings suggest strategies to block microorganisms from creating diseases in 1xbet online casino and humans, including the potential for antibiotic development and for therapeutic antibodies.
"It gives us insight," Klebba said. "Now we know that 1xbet online casino deprivation protects against disease, but we must be comprehensive and inhibit multiple systems to completely shut down the microorganisms' ability to obtain the metal."
The researchers are using their findings to isolate antibodies that block bacterial 1xbet online casino uptake. This may help animals and humans defend themselves against microbial diseases.
"We would like to apply this research and protect people from 1xbet online casino infection," Klebba said. "That's one of the focal points of our laboratory."
1xbet online casino 's research was supported by a .25 million grant from the National Institutes of Health.
The study was led by Hualiang Pi, Klebba's student at his former institution, the 1xbet online casino of Oklahoma. Another Kansas State 1xbet online casino collaborator on the project was Lorne Jordan, doctoral student in biochemistry,Toledo, Ohio.
The PLOS ONE article, by Hualiang Pi et al., -- titled "Role of Catecholate Siderophpores in Gram-negative 1xbet online casino Colonization of the Mouse Gut" -- is available athttp://dx.plos.org/10.1371/journal.pone.0050020.
