Vaccines developed for H5N1, H7N9 avian 1xbet online casino strains
Wednesday, May 20, 2015
Wenjun Ma, assistant professor of diagnostic medicine and pathobiology at Kansas State University, left, and Jürgen Richt, Regents distinguished professor of veterinary medicine and director of the U.S. Department of Homeland Security's Center of Excellence for Emerging and Zoonotic Animal Diseases, have developed vaccines for H5N1 and H7N9, two emerging strains of avian 1xbet online casino . The strains are zoonotic and can be transmitted from chickens to pigs and humans. | Download the following photo.
MANHATTAN — A recent study with Kansas State University researchers details vaccine development for two new strains of avian 1xbet online casino found in other countries that can be transmitted from poultry to humans. Those strains, not found in the U.S., have led to the culling of millions of commercial chickens and turkeys as well as the death of hundreds of people.
The new vaccine development method is expected to help researchers make vaccines for emerging strains of avian 1xbet online casino more quickly. This could reduce the number and intensity of large-scale outbreaks at poultry farms as well as curb human transmission.
It also may lead to new 1xbet online casino vaccines for pigs, and novel vaccines for sheep and other livestock, said Jürgen 1xbet online casino , Regents distinguished professor of veterinary medicine and director of the U.S. Department of Homeland Security's Center of Excellence for Emerging and Zoonotic Animal Diseases.
Richt and his colleagues focused on the avian influenza 1xbet online casino subtype H5N1, a new strain most active in Indonesia, Egypt and other Southeast Asian and North African countries. H5N1 also has been documented in wild birds in the U.S., though in fewer numbers.
"H5N1 is a zoonotic pathogen, which means that it is transmitted from chickens to humans," 1xbet online casino said. "So far it has infected more than 700 people worldwide and has killed about 60 percent of them. Unfortunately, it has a pretty high mortality rate."
Researchers developed a vaccine for H5N1 by combining two viruses. A vaccine strain of the Newcastle disease 1xbet online casino , a 1xbet online casino that naturally affects poultry, was cloned and a small section of the H5N1 1xbet online casino was transplanted into the Newcastle disease 1xbet online casino vaccine, creating a recombinant 1xbet online casino .
Tests showed that the new recombinant 1xbet online casino vaccinated chickens against both Newcastle disease 1xbet online casino and H5N1.
Researchers also looked at the 1xbet online casino flu subtype H7N9, an emerging zoonotic strain that has been circulating in China since 2013. China has reported about 650 cases in humans and Canada has reported two cases in people returning from China. About 230 people have died from H7N9.
"In Southeast Asia there are a lot of markets that sell live birds that people can buy and prepare at home," Richt said. "In contrast to the H5N1 1xbet online casino that kills the majority of chickens in three to five days, chickens infected with the H7N9 1xbet online casino do not show clinical signs of sickness. That means you could buy a bird that looks perfectly healthy but could be infected. If an infected bird is prepared for consumption, there is a high chance you could get sick, and about 1 in 3 infected people die."
Using the same method for developing the H5N1 vaccine, researchers inserted a small section of the H7N9 1xbet online casino into the Newcastle disease 1xbet online casino vaccine. Chickens given this recombinant vaccine were protected against the Newcastle disease 1xbet online casino and H7N9.
"We believe this Newcastle disease 1xbet online casino concept works very well for poultry because you kill two birds with one stone, metaphorically speaking," Richt said. "You use only one vector to vaccinate and protect against a selected 1xbet online casino strain of avian influenza."
Using the Newcastle disease 1xbet online casino for vaccine development may extend beyond poultry to pigs, cattle and sheep, Richt said.
Researchers found they were able to protect pigs against an H3 influenza strain by using the Newcastle disease 1xbet online casino to develop a recombinant 1xbet online casino vaccine. Wenjun Ma, Kansas State University assistant professor of diagnostic medicine and pathobiology, is building on this finding and using the Newcastle disease 1xbet online casino to make a vaccine for porcine epidemic diarrhea 1xbet online casino , a disease that has killed an estimated 6 million pigs.
Richt conducted the avian 1xbet online casino study with Ma, Adolfo Garcia-Sastre at the Icahn School of Medicine at Mount Sinai in New York, and several other colleagues. They published their findings in the Journal of Virology study, "Newcastle disease 1xbet online casino -vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses." It is the first study to look at an H7N9 vaccine in chickens, the animals the 1xbet online casino originates in.
