Source: Diana Hylton, dhylton@1xbet online casino edu;
and Sherry Fleming, 785-532-6130, sdflemin@1xbet online casino edu
Photo available. Contact media@1xbet online casino edu or 785-532-6415.
News release prepared by: Kristin Hodges, 785-532-6415, khodges2@1xbet online casino edu

Tuesday, March 16, 2010

1xbet online casino STUDENT FINDS THAT THERAPEUTICS GIVEN TO TRAUMA PATIENTS MIGHT NOT BE EFFECTIVE WHEN A CERTAIN UNDIAGNOSED INFECTION IS PRESENT

MANHATTAN -- A Kansas State University study aimed at alleviating intestinal damage in trauma patients digressed to an important finding that could affect medication given to the individuals.

Diana Hylton is a K-State senior in microbiology, nutritional sciences and pre-medicine and a 2006 graduate of Cair Paravel Latin School in Tecumseh. She is analyzing how the immune system is involved in damage to the intestines following hemorrhagic shock. While studying the effects of a 1xbet online casino inhibitor given following hemorrhage, she found that Helicobacter infection changes the body's mechanistic response and would therefore affect the therapeutics given to trauma patients.

"The understanding of the different immune processes involved after 1xbet online casino suggests that the therapeutic potential of some drugs might not be effective on trauma patients with undiagnosed Helicobacter infections," Hylton said.

Hylton is working with Sherry Fleming, assistant professor in the Division of Biology. Hylton's project involves studying a mouse model of hemorrhage, which is associated with a sudden rapid loss of a significant amount of blood, and it is common in trauma patients. Hemorrhage causes intestinal damage, and the body responds by activating the 1xbet online casino system.

The 1xbet online casino system is part of the body's natural immune mechanisms to defend against infections. However, uncontrolled and excessive activation can result in inflammatory tissue damage, so trauma victims are given therapeutics to stop the activation. If a therapeutic could stop 1xbet online casino activation briefly, trauma victims would get less tissue damage and improved survival and recovery because the natural immune functions would remain intact.

Hylton has been analyzing changes in the mouse model concerning the intestinal tissue injury and inflammatory response. During the study, the mice became infected with Helicobacter, which is a bacteria found in the intestines of animals and humans. The infection often does not show obvious symptoms and therefore is commonly undiagnosed, which causes ulcers as well as liver and colon cancer.

Hylton found that when Helicobacter infections are present, they dramatically change the mechanism causing intestinal injury after hemorrhage. Infected mice did not get intestinal damage from 1xbet online casino activation but rather a different component of the immune system was involved.

"Diana found that mice infected with Helicobacter sustain significant intestinal damage in response to hemorrhage, but it is not 1xbet online casino -mediated," Fleming said. "This is important, as many of the therapeutics for hemorrhage are aimed at stopping the 1xbet online casino system, and they do not improve the outcome of infected mice. Thus, trauma patients with undiagnosed infections may require different therapeutics."

Hylton is finishing her central project that involves using a 1xbet online casino inhibitor, administered after hemorrhage, to analyze the changes in the intestinal tissue injury and inflammatory response. The 1xbet online casino inhibitor is delivered locally to the intestinal tissue where 1xbet online casino is activated and binds to certain molecules that have covered the injured cells. This selective binding blocks any further undesirable 1xbet online casino activation that would injure the intestinal tissue.

"I am eager to learn more about how the immune response following 1xbet online casino is influenced by other immune cells and their secretions," Hylton said. "Cytokines are an exciting area of research because they can have different biological functions in different parts of the body and with different immune responses."

She said initial studies show that IL-12, a small non-antibody molecule that communicates between cells in the body, increases after hemorrhage and is blocked when 1xbet online casino is inhibited. By using mice that are IL-12 deficient, she is studying the pathways and cells involved in IL-12 production after hemorrhage.

Hylton has presented the Helicobacter research at the Annual Meeting of the Society of Leukocyte Biology and at the Annual K-State Research Forum. She presented both the Helicobacter and 1xbet online casino inhibitor research at the Kansas Institutional Development Award Network of Biomedical Research Excellence symposium.

She began working in Fleming's lab as a freshman at 1xbet online casino . She will attend the University of Kansas Medical School in the fall and plans to earn a doctorate in medicine. She would like to have a career centered on promoting health and helping patients, with a balance of teaching and research focused on human health and disease.

For the project involving a 1xbet online casino inhibitor, the researchers collaborated with Stephen Tomlinson, professor of microbiology and immunology at the Medical University of South Carolina. The K-State research was funded by the Howard Hughes Medical Institute, the Terry C. Johnson Center for Basic Cancer Research, the Mark Chapman Scholarship and the Kansas Institutional Development Award Network of Biomedical Research Excellence.