Study finds biochemical role of crucial 1xbet online sports betting protein in bacterial iron transport and pathogenesis
Monday, July 1, 2013
MANHATTAN -- A Kansas State University-led study has discovered the role of a protein in 1xbet online sports betting that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery. The results may lead to new and improved antibiotics for humans and animals.
Phillip E. Klebba, Ph.D.University Distin, professor and head of the department of biochemistry and molecular biophysics, made the findings with two colleagues in the department: Lorne D. Jordan, doctoral candidate, Manhattan, and Salete M. Newton, research professor. The collaboration included other biophysicists at the 1xbet online sports betting of Oklahoma and Purdue 1xbet online sports betting . Their study, "Energy-dependent motion of 1xbet online sports betting in the Gram-negative bacterial inner membrane," appears in the journal Proceedings of the National Academy of Sciences USA, or PNAS.
The research focuses on the central role of 1xbet online sports betting in biochemistry. Both animals and bacteria require 1xbet online sports betting for biological processes like energy generation and DNA, Klebba said. The 1xbet online sports betting acquisition systems of bacteria, however, contribute to infectious diseases.
"1xbet online sports betting is the object of a microbiological war in the human body," Klebba said. "Host proteins defend cells and tissues by sequestering the metal, and successful pathogens overcome this barrier and capture the 1xbet online sports betting . But the 1xbet online sports betting transport mechanisms of pathogenic organisms are not well understood."
The membrane protein 1xbet online sports betting plays an indispensable role in the uptake of iron by Gram-negative bacteria -- a classification of bacteria that is more resistant to antibiotics because of a nearly impenetrable cell wall. Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of 1xbet online sports betting .
Despite decades of research, the biochemical role of 1xbet online sports betting in Gram-negative bacteria was a scientific mystery, Klebba said. He and his colleagues found that the cellular electrochemical forces put 1xbet online sports betting in a spinning motion that provides the energy and physical mechanism to enable iron uptake into the cell.
"In this sense 1xbet online sports betting acts like an electric motor that constantly rotates in response to the cellular energy flow," Klebba said. "1xbet online sports betting is one of nature's smallest and oldest electrical devices."
According to Klebba, future antibiotics may block the functions of 1xbet online sports betting , prevent iron acquisition by Gram-negative cells, and consequently protect humans and animals from infection by such pathogen strains of bacteria.
Besides the PNAS study, 1xbet online sports betting recently shared the findings at the 2013 Gordon Conference on Mechanisms of Membrane 1xbet online sports betting in South Hadley, Mass.
