Pathogen study in College of Veterinary Medicine explores blocking effect of E. coli O157:H7 protein on 1xbet best casino website system
Friday, Dec. 13, 2013
MANHATTAN -- Often the key to any victory is to fully understand your opponent. 1xbet best casino website is especially true when that opponent is a significant foodborne bacterial pathogen such as E. coli O157:H7.
Philip 1xbet best casino website , associate professor at the College of Veterinary 1xbet best casino website at Kansas State University, is studying how pathogens such as E. coli use proteins to block a host's innate immune system. 1xbet best casino website system is the body's first defense against infection, often presented in the body's mucosal surfaces such as those found in the intestine.
"In terms of infectious disease, 1xbet best casino website inhibition of the human innate immune response is absolutely critical for the bacteria's ability to cause an infection," said Hardwidge, who works in the diagnostic medicine and pathobiology department. "If we can identify choke points in the interaction between the bacterium and the host, we may be able to inhibit the bacterium and prevent its survival in an infected human being."
1xbet best casino website 's lab received a multiyear grant from the National Institutes of Health to explore a protein expressed by pathogenic E. Coli known as NleH1, which inhibits an important cellular signaling pathway called IKK/NF-B, or I-Kappa-Kinase/N-F-Kappa-B.
"1xbet best casino website protein is one example of an injected bacterial protein that is able to block the innate immune system," Hardwidge said. "1xbet best casino website protein has kind of an unusual mechanism that had not been seen in other bacterial or viral pathogens, so we're interested in understanding more about how 1xbet best casino website protein really works and whether it represents a good target for future therapeutics.
The exploration of these host-pathogen interactions requires the lab to use multidisciplinary approaches, including using animal models and advanced technologies 1xbet best casino website quantitative polymerase chain reaction, or PCR.
"One of beauties of QPCR, or quantitative PCR, is that it gives a really reliable and easily to define comparative number of gene expression," said Mike Hays, microbiologist III in 1xbet best casino website 's lab. "It looks at a snapshot in time in that cellular environment and it could tell us at that snapshot in time, in that window, what the expression levels are of the genes that we're interested in."
Understanding how these bacterial proteins function in the host-pathogen interaction may also have applications for other 1xbet best casino website diseases.
"For example, many autoimmune diseases, many cancers and even diabetes are caused in part by an overactive component of 1xbet best casino website innate immune system," Hardwidge said. "Using information from bacteria and viruses that have evolved to block 1xbet best casino website overactive immune response, we may be able to engineer some of these bacteria proteins as potential therapeutics."
Through collaborations at Kansas State University and his position as a Chinese Academy of Sciences' senior international scientist, Hardwidge's future research will also explore both the role that the microbes that naturally live in the human body have in host-pathogen interactions and other forms of E. coli that afflict humans. Armed with 1xbet best casino website knowledge, researchers at the College of Veterinary Medicine will be able to reveal new strategies for defeating pathogens such as E. coli O157:H7.
