Source: Sherry 1xbet online games login 785-532-6130, sdflemin@k-state.edu
News release prepared by: Stephanie Jacques, 785-532-0101, sjacques@k-state.edu

Monday, Aug. 8, 2011

1xbet online games login DRAMA: K-STATE PROFESSOR RESEARCHES DRAMA QUEEN OF IMMUNE SYSTEM

MANHATTAN -- Kansas State University's Sherry Fleming is investigating the factor that initiates the immune system's &1xbet online games login ;drama queen&1xbet online games login ;: the one responsible for intestinal cell damage after hemorrhage.

1xbet online games login , an associate professor in the Division of Biology, is using a 0,000 grant from the American Heart Association to identify the molecule responsible for the overreaction that can cause cell death in the intestines after trauma.

&1xbet online games login ;What's starting this drama queen situation? A 13-year-old girl doesn't usually become a drama queen without a reason. There's something that initiated the drama -- clothes, shoes, make-up, movies, etc.,&1xbet online games login ; Fleming said. &1xbet online games login ;With hemorrhage, we're looking for the initiating factor in the drama which occurs after trauma.&1xbet online games login ;

After a traumatic event, such as the loss of a limb or severe bleeding, the body cuts off blood flow to the intestines, sending more blood to the vital organs like the heart, lungs and brain, 1xbet online games login said. During that time, cells in the gut release molecular markers to let the body know that they are not getting oxygen.

After the 1xbet online games login is resolved, blood flow is returned to the gut and a protein in the blood -- known as beta2 glycoprotein 1 in mice and apolipoprotein H in humans -- binds to the molecular marker on the cell to notify antibodies that there is a problem. The antibodies then activate a cascade of proteins, known as complement, that normally help the immune system by killing bacteria and helping rid tissues of dying cells. However, after a 1xbet online games login this system can overreact and unnecessarily kill healthy cells.

&1xbet online games login ;If you've been in a car accident and sever an arm or start hemorrhaging, you want complement there to protect you from bacteria. So we don't want to stop all complement action entirely,&1xbet online games login ; Fleming said.

But 1xbet online games login is looking for a way to interrupt the chain of events leading to the over activation of complement following a traumatic event, because trauma patients often develop further complications throughout their body due to the activation of complement, she said.

&1xbet online games login ;Many times trauma patients who have lost a lot of blood will end up with acute respiratory distress syndrome or multiple organ dysfunction syndrome, due to the complement system overreacting,&1xbet online games login ; Fleming said. &1xbet online games login ;So they not only have to deal with the trauma, but also with their immune system attacking things that it shouldn't.&1xbet online games login ;

As a possible solution, 1xbet online games login and her lab group have developed a peptide that takes the place of the beta2 protein in binding to the molecular marker on the cell's surface, thus preventing the activation of complement.

&1xbet online games login ;This treatment is a promising solution,&1xbet online games login ; Fleming said. &1xbet online games login ;The funding from the American Heart Association will give us the opportunity to make major progress in this research.&1xbet online games login ;