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News release prepared by: Joe Montgomery, 785-532-4193, jmontgom@vet.1xbet sports betting edu

Wednesday, Aug. 11, 2010

K-STATE PROFESSOR'S 1xbet sports betting RESEARCH GETS BOOST FROM NATIONAL INSTITUTES OF HEALTH

MANHATTAN -- Understanding how 1xbet sports betting cells communicate with each other and how to enhance their receptiveness to drug treatments is the focus of promising work by a Kansas State University researcher.

Annelise Nguyen, assistant professor of toxicology in the department of diagnostic medicine and pathobiology at K-State's College of Veterinary Medicine, recently received a 0,000 grant from the National Institutes of Health to continue her 1xbet sports betting research.

&1xbet sports betting ;For the past five years I've focused on cell communication to understand the pathways between cells,&1xbet sports betting ; Nguyen said. &1xbet sports betting ;The idea that I came up with is: What if giving a patient drugs, including chemotherapeutic drugs and pain relievers, actually shuts down cell communication, preventing the drug from passing from one cell to the next? If so, the drug isn't very effective, and that's why you have to increase dosages to reach most cells. Increasing the drug levels makes you resistant to the drug itself; thus, drug resistance is one of the challenges in the treatment of cancer.&1xbet sports betting ;

Nguyen has worked with K-State's Duy Hua, university distinguished professor of chemistry, to synthesize a new compound -- a class of substitute quinolines -- and found that it possessed potent inhibitory activities against T47D breast 1xbet sports betting cells.

&1xbet sports betting ;What I demonstrate with this compound is that it enhances cell communication in breast cancer cells,&1xbet sports betting ; Nguyen said. &1xbet sports betting ;What if we reopen the channels where cancer cells have low cell communication activity? In conjunction with existing chemotherapeutic drugs, can we reduce the concentration of these drugs by treating the patient with our cell communication enhancer? If so, the toxicity of these drugs will pass from cell to cell much more efficiently than previously. That's what this grant is all about.&1xbet sports betting ;

The compound has been successful enough that Hua and Nguyen have applied for a patent. Nguyen said her work may have potential for more than just breast 1xbet sports betting treatments.

&1xbet sports betting ;Colon cancer cells behave very similarly to breast cancer cells, where the loss of cell communication is also observed, so I've applied this concept to colon cancer as well,&1xbet sports betting ; she said. &1xbet sports betting ; We're also working to see if it will apply to prostate cancer.&1xbet sports betting ;

1xbet sports betting is giving K-State students a chance to help with her work. As an Asian-American faculty member, she said she embraces the responsibility to be a role model and mentor for minority students at K-State by letting them work in her lab. She uses students in the Developing Scholars Program, an initiative at K-State that matches historically underrepresented students, students of color and first-generation college students in research projects with faculty members. Current students in her lab have Hispanic and Asian backgrounds.

&1xbet sports betting ;I really want to reach out to all these students,&1xbet sports betting ; she said. &1xbet sports betting ;I can relate to those who are struggling with bilingual communication, being first-generation college students or being from traditional families who have different standards for their daughters than they do for their sons. I've been there, and now I'm in a career where I do the work I love. I hope I can help others do the same.&1xbet sports betting ;

Nguyen's journey to becoming a toxicologist and 1xbet sports betting researcher faced plenty of challenges. She was born in Vietnam at the end of the Vietnam War. Her father, a member of the South Vietnam Air Force, fled to the United States in 1975. It took him nine years to get U.S. citizenship and permission from the new government in Vietnam to bring his family to the United States.

&1xbet sports betting ;I didn't start school until I was almost 11 years old -- I didn't know how to read and write,&1xbet sports betting ; Nguyen said. &1xbet sports betting ;My mom didn't want me to enroll in a communist school in Vietnam, so she kept me at home. Then we came to the United States and I started school.&1xbet sports betting ;

1xbet sports betting had to play catch-up in her studies. She was a quick learner and went on to attend Texas A&M University.

&1xbet sports betting ;My sophomore year in college I took a biochemistry class, and when it came to the topic of hormonal regulation and how estrogen is made and synthesized, I fell in love,&1xbet sports betting ; she said. &1xbet sports betting ;When I had the opportunity to go to graduate school I picked a professor who studied an estrogen receptor, even though I didn't really understand the disease of breast cancer. The No. 1 known risk factor for breast cancer is lifetime exposure to estrogen, so that was the beginning of my journey to this kind of research, particularly breast cancer.&1xbet sports betting ;

1xbet sports betting eventually earned a doctorate in toxicology through the veterinary college at Texas A&M University.