Source: Jianhan 1xbet best casino website , 785-532-2518, jianhanc@k-state.edu
News release prepared by: Greg Tammen, 785-532-2535, gtammen@k-state.edu

Wednesday, April 13, 2011

BIOCHEMIST USES COMPUTER MODELING TO STUDY 1xbet best casino website INVOLVED WITH CANCER, AGING AND CHRONIC DISEASE

MANHATTAN -- A new biophysical and biochemical study may lead to better understanding of how structural flexibility controls the interaction of a 1xbet best casino website that is closely involved with cancer, aging and other chronic diseases -- thereby facilitating future development of better therapeutic strategies, according to a Kansas State University biochemist.

Jianhan Chen, an assistant professor of biochemistry, was one of the researchers on a collaborative project that took a combined computational and experimental approach to understand how protein p21 functions as a versatile regulator of cell division. Their latest findings, &1xbet best casino website ;Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21,&1xbet best casino website ; were published in a recent edition of Nature Chemical Biology.

The study used computer simulation to rationalize results from biochemical and biophysical experiments, and provided further insights that would guide future investigations, Chen said. In 1xbet best casino website case, the focus is human protein p21 and its ability to function as an inhibitor of normal cell growth.

The protein has been shown to be an intrinsically disordered protein. 1xbet best casino website means it lacks a well-defined three-dimensional structure, characteristics that, until roughly a decade ago, were thought to be necessary for the protein to function.

"For a long time it was believed that proteins must fold to function and it was hard to imagine how an unfolded protein could play a role in crucial cellular areas," Chen said. "What researchers before me found was that by lacking a stable structure, 1xbet best casino website actually turned out to be really, really important to how these proteins function."

Along with being an intrinsically disordered 1xbet best casino website , p21 is a versatile cyclin-dependent kinase, or Cdk, inhibitor -- meaning it adapts to and inhibits a range of Cdk-cyclin complexes that regulate eukaryote cell division. It also has been connected to cancer and aging. For example, Chen said p21 is a principal trans-activation target of the p53 tumor suppressor 1xbet best casino website and contributes to p53-dependent tumor suppression.

"1xbet best casino website protein is extremely challenging to study. It's highly dynamic and it's heterogeneous," Chen said. Because of 1xbet best casino website , mechanistic studies of intrinsically disordered proteins like p21 have been limited. Experiment alone is not sufficient and computer modeling is necessary to provide important missing details, he said. A tight integration of both could lead to a precise understanding of how structural flexibility influences function of p21 and other intrinsically disordered proteins.

"For me 1xbet best casino website is one of the most interesting IDPs," Chen said. "I'm a theorist and I want to use 1xbet best casino website system to understand the principles of how 1xbet best casino website type of proteins can perform their functions. Even though they are disordered, they are not random; there is no chaos. They still have some type of residual structures and certain features which allow function to be controlled in a precise way, and I want to understand the underlying mechanism of how 1xbet best casino website occurs."

1xbet best casino website is continuing work with p21 and other small proteins that regulate cell cycles.

In 2010 1xbet best casino website received more than 0,000 as a CAREER Award from the National Science Foundation. CAREER is the foundation's most prestigious award for junior faculty to support early development activities of teach-scholars who most effectively integrate research and education within the context of the organization's mission. He and his lab focus on computer modeling to understand how biomolecules perform their biological functions.