Source: Angela 1xbet online casino , dahl1545@k-state.edu
Photo available. Download at http://www.k-state.edu/media/newsreleases/apr11/angelagrommet.jpg
News release prepared by: Tyler Sharp, 785-532-2535, media@k-state.edu

Thursday, April 28, 2011

PASSION FOR CHEMISTRY FUELS WICHITA SOPHOMORE'S 1xbet online casino TO IMPROVE PAINKILLERS

MANHATTAN -- Food packages and medicine bottles often list a dizzying array of chemicals and ingredients on their labels.

But for Kansas State University chemistry major Angela 1xbet online casino , reading the ingredients isn't confusing -- it's interesting.

1xbet online casino was introduced to chemistry in high school and has never looked back.

&1xbet online casino ;I thought it was the most interesting subject I had ever studied. It explained so many things about the world in which we live,&1xbet online casino ; she said. &1xbet online casino ;Today I think of chemistry as a tiny 3-D puzzle on which all things depend -- it's fascinating.&1xbet online casino ;

Grommet's interest in chemistry has led her to the 1xbet online casino lab, where the sophomore from Wichita is studying the use of co-crystallization to manipulate the aqueous solubility of diclofenac, a painkiller used to treat rheumatoid arthritis. Diclofenac has two forms: one dissolves in the bloodstream quickly, while the other barely dissolves.

The goal of the 1xbet online casino is to develop a form of the drug that dissolves at a rate between the two, creating long-lasting pain relief instead of instant pain relief. Grommet has been conducting her 1xbet online casino with Christer Aakeroy, professor of chemistry, since January 2010. So far her project has revealed that chemists have the knowledge to change the natural binding patterns of compounds like diclofenac.

&1xbet online casino ;We've discovered 12 compounds that co-crystallize successfully with diclofenac,&1xbet online casino ; she said. &1xbet online casino ;These co-formers were carefully selected because they possessed hydrogen bond acceptor sites, which were more attractive than the acceptor sites on diclofenac itself.&1xbet online casino ;

Limiting pain is also the focus of Grommet's other 1xbet online casino project, which has been ongoing since June 2010. The project is attempting to combine two separate and compatible drugs into a single unit. This new drug would have the ability to fight pain and cancer simultaneously. The two drugs will be combined at the molecular level through co-crystallization.

&1xbet online casino ;Our goal is to show that different active pharmaceutical ingredients can be co-crystallized together,&1xbet online casino ; Grommet said.

The 1xbet online casino has already revealed eight different anticancer agents that co-crystallize successfully with diclofenac during solvent assisted grinding. Grommet is conducting the 1xbet online casino with Aakeroy. Currently, crystals are being grown to submit so the structure of the new co-crystals can be determined.

For a student with such diverse 1xbet online casino interests, Grommet entered K-State unaware of how much she would enjoy the process.

&1xbet online casino ;The faculty here could not be more supportive of undergraduate research,&1xbet online casino ; she said. &1xbet online casino ;My success thus far is largely a tribute to my mentors at K-State.&1xbet online casino ;

1xbet online casino graduated from Andover High School in 2009. She is the daughter of Gary and Anne 1xbet online casino , Wichita. She also was one of K-State's four nominees for the 2011 Barry M. Goldwater Scholarship.