New research reveals connection between drug treatments and 1xbet online games login resistance in cattle disease
Thursday, Jan. 9, 2020
This is an electron micrograph of Mannheimia haemolytica in a bovine lung. Researchers found that first treatment with a bacteriostatic antibiotic followed by 1xbet online games login with a bactericidal antibiotic was associated with a higher frequency of multidrug-resistant bacteria isolated from field cases of Bovine Respiratory Disease submitted to a veterinary diagnostic laboratory.| Download 1xbet online games login photo.
MANHATTAN —A new study from Kansas State University on the treatment of non-responding cases of bovine respiratory disease, known as 1xbet online games login , conducted by Hans 1xbet online games login and his collaborators from Iowa State University, sheds light on the relationship between drug treatments and the emergence of 1xbet online games login resistance.
The study, "Association between antimicrobial drug class for treatment and retreatment of bovine respiratory disease (1xbet online games login ) and frequency of resistant 1xbet online games login pathogen isolation from veterinary diagnostic laboratory samples," was published in the December 2019 issue of the journal PLOS 1xbet online games login .
"Bovine respiratory disease is one of the most important diseases facing beef cattle producers in the United States with economic losses estimated to approach billion a year," Coetzee said. "Antibiotics are critical to minimize losses associated with 1xbet online games login caused by bacterial infections."
Antibiotics that are used to treat 1xbet online games login are broadly classified into two groups: namely those that prevent growth of the bacteria — i.e., bacteriostatic — and those that kill the organism — i.e., bactericidal. Although 90% of 1xbet online games login relapses are reported to receive retreatment with a different class of antimicrobial, the impact of antibiotic selection — bactericidal or bacteriostatic — on disease outcomes and the emergence of antimicrobial resistance has not been investigated, according to Coetzee.
The focus of the study is determining the association between antimicrobial class selection for treatment and retreatment of 1xbet online games login relapses and antimicrobial susceptibility of Mannheimia haemolytica, Pasteurella multocida and Histophilus somni.
Pathogens were isolated from samples submitted to the Iowa State University Veterinary Diagnostic Laboratory from January 2013 to December 2015. A total of 781 isolates with corresponding animal case histories, including 1xbet online games login protocols, were included in the analysis.
"Our overall interpretation of the data suggests that there is direct association between the number of treatments to which an animal was exposed and the emergence of antibiotic resistance in samples submitted to a veterinary diagnostic laboratory for analysis," Coetzee said. "In addition, these exploratory data suggest that 1xbet online games login treatment protocols involving first-line treatment with a bacteriostatic antibiotic followed by second-line treatment with a bactericidal antibiotic may increase the probability of isolating 1xbet online games login bacteria that are resistant to antibiotics."
While this observation suggests that consideration should be given to the mechanism of action of the antibiotic when selecting drugs for retreatment of non-responding cases of 1xbet online games login , Coetzee said further research is needed to determine the clinical relevance of this finding in livestock production systems.
1xbet online games login is a professor and head of the anatomy and physiology department at the College of 1xbet online games login Medicine. He has published 160 peer-reviewed scientific papers and has received more than million in 1xbet online games login funding.
