Scientists, Biosecurity Research Institute study 1xbet online games login to prevent outbreak in US
Monday, Oct. 8, 2018
Kansas State University researchers and the Biosecurity Research Institute have several projects focused on stopping the spread of 1xbet online games login and preventing it from reaching the U.S.| Download this photo.
MANHATTAN —1xbet online games login virus threatens to devastate the swine industry and is positioned to spread throughout Asia. The virus has spread throughout the Caucuses region of Eastern Europe and was reported in China in August. It recently was detected in wild boar in Belgium.
Kansas State University researchers and the Biosecurity Research Institute have several projects focused on 1xbet online games login . Their research topics vary, but they share the same goal of stopping the spread of 1xbet online games login and preventing it from reaching the U.S.
If 1xbet online games login enters the U.S., it could cause billions in economic losses to swine and other industries, animal disease experts say. It would devastate trade and international markets.
There is no vaccine or cure for the disease, which causes hemorrhagic fever and high mortality in pigs. It does not infect humans.
"1xbet online games login 's introduction into China poses an increased threat to the U.S.," said Stephen Higgs, director of the Biosecurity Research Institute. "Introduction of 1xbet online games login virus into the U.S. would have an enormous impact on our agricultural industry. Research, education and training at the Biosecurity Research Institute help to improve our understanding and preparedness for this threat."
In 2013, the Biosecurity Research Institute became the first non-federal facility to be approved for work with 1xbet online games login virus, Higgs said. The university projects at the Biosecurity Research Institute are part of research that can transition to the National Bio and Agro-defense Facility, or NBAF, once it is fully functional. 1xbet online games login is one of the diseases slated to be researched at NBAF, which is under construction adjacent to Kansas State University's Manhattan campus.
The 1xbet online games login projects at Kansas State University are funded in part by the million State of Kansas National Bio and Agro-defense Facility Fund and also have received support from the U.S. Department of Homeland Security and the pork industry.
Read Stephen Higgs' editorial on 1xbet online games login , which recently was published in Vector-Borne and Zoonotic Diseases.
Here are some of the Kansas State University faces behind the fight against 1xbet online games login .
Ying Fang
Name:Ying Fang, professor of diagnostic medicine and pathobiology in the College of Veterinary MedicinePhoto: k-state.edu/media/images/oct18/fang.jpg
Areas of study related to 1xbet online games login : Vaccine and diagnostic reagent/assay development.
Description of the research: Fang’s lab has generated 1xbet online games login virus-specific monoclonal antibodies for diagnostic assay development. In a collaborative project with Raymond "Bob" Rowland, professor of diagnostic medicine and pathobiology, and Biao He at the University of Georgia, her lab also is developing vector vaccines against 1xbet online games login infection.
Why the research is important: "Recent 1xbet online games login outbreaks in China and now Europe pose the potential pandemic threat to global swine industry," Yang said. "Specific diagnostic assays and effective vaccines are urgently needed for disease control and prevention."
More information: vet.k-state.edu/education/dmp/faculty-staff/faculty/fang/index.html
Waithaka Mwangi
Name:Waithaka Mwangi, associate professor of diagnostic medicine and pathobiology in the College of Veterinary Medicine.
Photo: k-state.edu/media/images/oct18/mwangi.jpg
Areas of study related to 1xbet online games login : Vaccine development and diagnostic tools.
Recent 1xbet online games login -related research: Publication in PLOS ONE; publication in Veterinary Immunology and Immunopathology; publication in Clinical and Vaccine Immunology; publication in the Journal of General Virology
Description of the research: Mwangi has been studying 1xbet online games login for several years and has filed patents related to development of vaccines and diagnostic tools. In his latest research, Mwangi and Raymond "Bob" Rowland, professor of diagnostic medicine and pathobiology, as well as Shehnaz Lokhandwala, postdoctoral fellow in diagnostic medicine and pathobiology, have tested vaccine prototypes at the Biosecurity Research Institute. Some of their vaccines have shown 56 percent protection against 1xbet online games login and they have several studies pending to evaluate additional vaccine prototypes.
Mwangi's lab also is developing diagnostic tools, including a highly-sensitive lateral flow diagnostic device for 1xbet online games login . He is partnering with several companies and has received funding from the Department of Homeland Security, the National Pork Board and the Department of Agriculture as well as the State of Kansas National Bio and Agro-defense Facility Fund.
Why the research is important: "1xbet online games login is a high-consequence transboundary animal disease for which there is no vaccine or treatment available," Mwangi said. "Thus, development of vaccines and a diagnostic test capable of differentiating infected from vaccinated animals is critically important to safeguard the swine industry and preserve future competitiveness of the U.S. pork industry. In addition, these vaccines will help in controlling virus spread in endemic regions and thereby minimize the transmission threat to the U.S."
More information:vet.k-state.edu/education/dmp/faculty-staff/faculty/mwangi/mwangi.html
Megan Niederwerder
Name:Megan Niederwerder, assistant professor of diagnostic medicine and pathobiology in the College of Veterinary Medicine.Photo: k-state.edu/media/images/oct18/niederwerder.jpg
Areas of study related to 1xbet online games login : Risk of virus introduction and transmission through feed or feed ingredients and potential mitigation tools.
Recent 1xbet online games login -related research: Publication in PLOS ONE
Description of the research: Niederwerder's latest research has found that 1xbet online games login virus could survive in a simulated feed shipment across the ocean, which suggests that feed may be a potential route that pathogens such as 1xbet online games login virus spread. Her recent publication in the journal PLOS ONE is the first publication demonstrating the survival of 1xbet online games login virus in feed ingredients.
Niederwerder is collaborating with the Biosecurity Research Institute to continue studying the risk of 1xbet online games login virus in feed and feed ingredients. She is studying the whole swine feed transport cycle — from the shipment of feed ingredients as they are imported into the U.S. to when swine consume feed on the farm. Niederwerder also is investigating potential mitigation strategies, such as storage time and chemical mitigants, to reduce the risk of 1xbet online games login virus in feed.
Why the research is important: "Although feed is a less recognized transmission route for 1xbet online games login , the global distribution of feed and feed ingredients makes this route important to consider as a possible factor in transboundary spread," Niederwerder said. "Our research is focused on understanding the role that feed plays in viral transmission, through defining the oral infectious dose and stability in feed ingredients, and learning what mitigation tools may be utilized to reduce the risk of 1xbet online games login virus introduction into the U.S."
More information: 1xbet online sports betting the spread of the disease
Jürgen Richt
Name:Jürgen Richt, Regents distinguished professor and director of the university's Center of Excellence for Emerging and Zoonotic Animal Diseases, or CEEZAD.
Photo: k-state.edu/media/images/oct18/richt.jpg
Areas of study related to 1xbet online games login : Novel vaccines and diagnostic approaches.
Recent 1xbet online games login -related research: Publications from the Center of Excellence for Emerging and Zoonotic Animal Diseases
Description of the research: Richt was principal investigator of a CEEZAD-based research project that developed an approach based on prime-boost vaccination, combining 1xbet online games login virus antigens encoded by DNA plasmids and recombinant 1xbet online games login virus proteins with the aim to activate both humoral and cellular immunity. Richt also has developed gene-deleted 1xbet online games login viruses to be used as modified live virus vaccines using CRISPR-Cas9 knock-out approaches in collaboration with Yolanda Revilla at Centro de Biologia Molecular Severo Ochoa in Madrid.
In diagnostics, Richt leads CEEZAD efforts to develop tests for the detection of markers of 1xbet online games login virus and anti-1xbet online games login virus antibodies in different samples such as oral fluids and meat juice. Work is also being done on 1xbet online games login virus detection using a portable detection device.
Why the research is important: "1xbet online games login presents a serious and ongoing threat to the swine industry both in the United States and around the world, particularly with its recent spread through Eastern Europe and into China," Richt said. "It is imperative to the safety of our food supply and to our economic health that we pursue research into a solution to this important threat."
More information:k-state.edu/media/newsreleases/2018-08/asf82118.html and ceezad.org
Raymond "Bob" Rowland
Name:Raymond "Bob" Rowland, professor of diagnostic medicine and pathobiology in the College of Veterinary MedicinePhoto: k-state.edu/media/images/oct18/rowland.jpg
Areas of study related to 1xbet online games login : Novel approaches for detection and control, capacity building and training, outreach to stakeholder communities.
Recent 1xbet online games login -related research: Publication in PLOS ONE; publication in Journal of Veterinary Diagnostic Investigation; publication in Nature’s Scientific Reports; publication in Virology
Description of the research: Rowland’s lab has received support from the State of Kansas National Bio and Agro-defense Facility Fund and was the first to work with 1xbet online games login at the Biosecurity Research Institute. His research focuses on developing tools to prevent the entry of the virus into the U.S. He has developed an assay that rapidly and accurately detects 1xbet online games login infection in blood, feces and oral fluid samples. These assays will be important for routine surveillance of commercial pig herds and feral pigs. Rowland is collaborating with Ying Fang, professor of diagnostic medicine and pathobiology, and the Foreign Animal Disease Diagnostic Laboratory to characterize antibodies that can improve the accuracy of existing 1xbet online games login assays.
The Rowland lab is working with Fang and Waithaka Mwangi,associate professor of diagnostic medicine and pathobiology, to explore vaccine development by preparing vector libraries to find a combination of antigens and antigen-delivery platforms that can deliver protective immunity. Rowland also is collaborating with the Lawrence Livermore National Laboratory and the Australian Animal Health Laboratory to identify gene pathways associated with disease and the recovery of pigs from infection.
Why the research is important: "There is no single ‘magic bullet’ solution for the prevention of 1xbet online games login ," Rowland said. "As a global problem, preventing and controlling 1xbet online games login virus require new technologies and new knowledge along with the continuous fine-tuning of the existing tools. The greatest gap in knowledge addressed by this research is to better understand 1xbet online games login virus immunity in pigs. Filling this gap opens the door to improved disease surveillance methods, pigs with improved response to vaccination, and vaccines that are safe, cost-effective and protective."
More information: vet.k-state.edu/education/dmp/faculty-staff/faculty/rowland/
Adrian Self
Name:Adrian Self, prospect director with the university's National Agricultural Biosecurity Center.Photo: k-state.edu/media/images/oct18/self.jpg
Areas of study related to 1xbet online games login : Risk analysis.
Recent 1xbet online games login -related research: Publication in PLOS One; publication in Transboundary and Emerging Diseases; publication in BioResearch Open Access
Description of the research: The university's National Agricultural Biosecurity Center is studying 1xbet online games login through its NBAF Transition Transboundary Animal Disease risk analysis project. The project is developing timely and accurate qualitative and quantitative risk analysis for diseases, such as 1xbet online games login , that will be studied at NBAF. The project involves a university team of epidemiologists and student researchers as well as collaborators in engineering, veterinary medicine, social science and agricultural communications. The team is using rural communities in Kansas as models to develop contacts and communication methods that helps distribute accurate information in a timely manner.
Why the research is important: "It is critical to be able to quickly and accurately identify 1xbet online games login to prevent its further spread," Self said. "We want to stop this virus from reaching the U.S. and it is crucial to understand the risks and develop a communication infrastructure now, especially with the communities and with the stakeholders who could be most affected by the spread of this devastating virus."
More information: k-state.edu/nabc
Jishu Shi
Name:Jishu Shi, professor of vaccine immunology in the College of Veterinary Medicine.
Photo:k-state.edu/media/images/oct18/shi.jpg
Areas of study related to 1xbet online games login : Virus detection, vaccine development and transmission.
Recent 1xbet online games login -related research: Publication in the Journal of Virological Methods
Description of the research: Shi's lab studies 1xbet online games login virus detection, vaccine development and transmission between feral and domestic pigs. Shi has worked with Jianfa Bai, director of molecular research and development at the Kansas State Veterinary Diagnostic Laboratory, and other collaborators to develop and validate a multiplex polymerase chain reaction that can simultaneously detect 1xbet online games login virus, classical swine fever virus, and foot-and-mouth disease virus in one sample. Shi's lab currently is developing novel technologies that can be used to develop 1xbet online games login vaccines. After the recent outbreak in China, Shi is establishing new collaborations to study the transmission of the virus between wild and domestic pigs.
Why the research is important: "The most effective defense against foreign animal diseases such as 1xbet online games login , classical swine fever, and foot-and-mouth disease is to keep them outside the U.S.," Shi said. "That is why we have developed fast and sensitive virus detection methods such as the multiplex polymerase chain reaction panel for 1xbet online games login virus, classical swine fever virus and foot-and-mouth disease virus. We are developing new technologies that can be used to create an efficacious 1xbet online games login vaccine. Before an efficacious vaccine is available, we have to understand and develop novel strategies to control the disease spillover between wild and domestic pig populations."
More information:vet.k-state.edu/education/anatomy-physiology/faculty-staff/faculty/shi/
