K-State researchers are working on a method of delivering cancer drugs that promises to increase efficiency and reduce side effects.
&1xbet best casino website ;Although chemotherapy has saved many lives, it often has undesirable side effects,&1xbet best casino website ; said Deryl Troyer, professor of anatomy and physiology at the College of Veterinary Medicine. &1xbet best casino website ;The people most excited about this research are people who have gone through chemo, because our approach may circumvent many of those side effects.&1xbet best casino website ;
Troyer and two other faculty members -- Duy Hua, university distinguished professor of chemistry, and Masaaki Tamura, associate professor of anatomy and physiology -- received a 0,000 grant from the National Institutes of Health. They are studying how stem 1xbet best casino website can be used to deliver anti-cancer drugs directly to breast cancer 1xbet best casino website via nanoparticles. The researchers have studied the method in vitro but soon hope to study the method in preclinical models. The research is a part of the program of the Midwest Institute for Comparative Stem Cell Biology at K-State and has received support from K-State's Terry C. Johnson Center for Basic Cancer Research.
The researchers are using stem 1xbet best casino website isolated from Wharton's jelly, the substance that cushions blood vessels in the umbilical cord. These stem 1xbet best casino website can be harvested noninvasively and therefore are not controversial.
&1xbet best casino website ;Billions and billions of these cells are disposed of every day,&1xbet best casino website ; Troyer said. &1xbet best casino website ;We think these cells have a lot of advantages, including their ability to be harvested in large numbers very rapidly.&1xbet best casino website ;
Troyer said the stem 1xbet best casino website display a homing ability in that they tend to travel to tumors and other pathological lesions. The researchers are using these stem 1xbet best casino website as delivery systems by loading the 1xbet best casino website with nanoparticles that contain anti-cancer drugs.
&1xbet best casino website ;We are using the cells as stealth vehicles,&1xbet best casino website ; Troyer said.
Hua is fabricating the nanoparticles and some of the small-molecule drugs for the research. The tiny capsules are &1xbet best casino website ;nanogels&1xbet best casino website ; made up of two polymers. The nanogel has a dye molecule that allows the researchers to follow it through the body.
The nanogel capsules are loaded into a stem cell, which responds to proteins sent out by the cancer 1xbet best casino website by homing to them, Hua said. As the stem 1xbet best casino website reach the cancer tissues, another chemical that induces death of the stem 1xbet best casino website will be administered – only stem 1xbet best casino website are engineered to respond to this additional drug. This means that the nanogel-encapsulated drugs will be released from the stem 1xbet best casino website directly at the cancer tissue.
&1xbet best casino website ;The nanogel can be viewed as a very tiny piece of paper that wraps around the anti-cancer drug like a candy wrapper,&1xbet best casino website ; Hua said. &1xbet best casino website ;Over time or under certain conditions, the paper unwraps and releases the candy. Most anti-cancer drugs, including ours, are insoluble in water. However, the nanogel is water soluble.&1xbet best casino website ;
Because the drugs are going directly to cancer 1xbet best casino website , Troyer said this method could cause fewer side effects than less direct methods like intravenous chemotherapy. Troyer said that this research will make existing but underused cancer drugs more useful.
&1xbet best casino website ;Many potent small-molecule drugs are sitting on a shelf collecting dust,&1xbet best casino website ; Troyer said. &1xbet best casino website ;Often they are insoluble or have many toxic effects. We hope to deliver some of these compounds in a more targeted manner via the combination of stem cells and nanoparticles. Although nanotechnology has made enormous strides toward more focused drug delivery, there is always room for improvement.&1xbet best casino website ;