Department of Chemistry
Ping Li

Dr. Ping li 1xbet sports betting
Associate Professor
location CBC 303
phone 785-532-6431 (office)
email pli@ksu.edu
Research Themes

Design and Synthesis of Molecules and Supramolecular Architecturesblank spacerFunctional Materials, Catalysis, and Nanochemistryblank spacerEnergy, Environment, Agriculture, and Sustainability
Lab Website Link phone 785-532-2579 (lab)

biography 1xbet sports betting
2017-Pres.
2011-2017
2006-2011
2005-2006
1999-2004		 Associate Professor
Assistant Professor
NIH Postdoctoral Fellow, Massachusetts Institute of Technology
Postdoctoral Fellow, Duke University
Ph.D., Duke University

Research overview 1xbet sports betting

Using enzymology, synthetic organic chemistry, and molecular biology as major tools to 1xbet sports betting and manipulate biologically important enzymes/proteins. Currently, I have three projects in my lab.

  1. Polyhydroxyalkanoate (1xbet sports betting ) biosynthesis, regulation, and utilization.
    PHAs are carbon storage polymers produced by a variety of bacteria under conditions that limit nutrients except for carbon. The environmentally friendly PHA bioplastics are considered as an ideal alternative to petroleum-derived plastics that are non-biodegradable. Our goal is to understand PHA homeostasis at the molecular level such that metabolic- and 1xbet sports betting -engineering in bacteria can be performed to produce PHA polymers economically. Moreover, study of PHA production can serve as a paradigm to understand widespread template-independent polymerizations where the mechanism remains enigmatic.
  2. Bacterial enzymes involved in 1xbet sports betting .
    Lignin is a recalcitrant polymer consisting of various phenylpropane-based monomers linked together by C-C and C-O-C bonds, which is the most abundant renewable carbon source on earth next to cellulose. The cost of 1xbet sports betting has been a major indicator for the competitiveness of biofuels vs. petroleum-based gasoline. It is well known that fungus contains a series of redox metalloenzymes that can efficiently degrade lignin. However, until now they have not been used at industrial scales due to difficulties in modulation of fungal genetics and production of fungal proteins. Therefore, there is a paradigm shift to seek for bacterial enzymes for 1xbet sports betting . Our goal is to identify and develop them into a system that can be used to process 1xbet sports betting economically at large scales.
  3. 1xbet sports betting methyltransferases in epigenetics.
    Methylation is one of commonly observed 1xbet sports betting posttranslational modifications that play important roles in signaling network and epigenetic regulation. Defects in the methylation have been linked to various diseases including cancers, neurological disorders, and abnormalities in development. Aside from 1xbet sports betting lysine and arginine methyltransferases, a new type of 1xbet sports betting methyltransferases, α-N-terminal RCC1 methyltransferases (NRMTs), was recently discovered in eukaryotes and human. Limited 1xbet sports betting NRMTs suggests that they may be linked to cancers. Our goal is to identify the processes and/or targets involving NRMT for potential cancer therapy.

Selected publications
  1. Zhou, Q., Wu, W., Jia, K., Qi, G., Sun, X.S., Li, P.* Design and characterization of PROTAC degraders specific to 1xbet sports betting N-terminal methyltransferase 1. Eur. J. Med. Chem. 2022, 244: 114830, DOI: 10.1016/j.ejmech.2022.114830.
  2. Li, Q., Qi, G., Lutter, D., Beard, W., Souza, C.R., Highland, M.A., Wu, W., Li, P., Zhang, Y., Atala, A., Sun, X.S. Injectable peptide hydrogel encapsulation of mesenchymal stem cells improved viability, stemness, anti-inflammatory effects, and early stage wound healing. Biomolecules 2022, 12: 1317, DOI: 10.3390/biom12091317.
  3. Pradyawong, S., Shrestha, R., Li, P., Sun, X.S., and Wang, D. Effect of pH and pH-shifting on lignin–1xbet sports betting interaction and properties of lignin-1xbet sports betting polymers. J. Polym. Environ. 2022, 30, 1908-1919, DOI: 10.1007/s10924-021-02319-8.
  4. Shrestha, R., Jia K., Khadka S., Eltis L.D., and Li P.* Mechanistic insights into DyPB 1xbet sports betting Rhodococcus jostii RHA1 via kinetic characterization, ACS Catal. 2021, 11, 5486-5495, DOI: 10.1021/cascatal.1c00703.
  5. Jia, K., Huang, G., Wu, W., Shrestha, R., Wu, B., Xiong, Y., and Li, P.* In vivo 1xbet sports betting of OLA1 revealed by activity-based target profiling of NTMT1, Chem. Sci. 2019, 10, 8094-8099, DOI: 10.1039/C9SC02550B.
    *Highlighted as a back-cover article .
  6. Shrestha, R., Huang, G., Meekins, D., Geisbrecht, B.V., and Li, P.* Mechanistic insights 1xbet sports betting dye-decolorizing peroxidase revealed by solvent isotope and viscosity effects, ACS Catal. 2017, 7, 6352-6364, DOI: 10.1021/acscatal.7b01861.
  7. Huang, G., Shrestha, R., Jia, K., Geisbrecht, B.V., and Li, P.* Enantioselective synthesis of dilignol model compounds and their stereodiscrimination 1xbet sports betting with a dye-decolorizing peroxidase, Org. Lett., 2017, 19, 1820-1823, DOI: 10.1021/acs.orglett.7b00587.
  8. Shrestha, R., Chen, X., Ramyar, K. X., Hayati, Z., Carlson, E. A., Bossmann, S. H., Song, L., Geisbrecht, B.V., and Li, P.* Identification of surface-exposed 1xbet sports betting radicals and a substrate oxidation site in A-class dye-decolorizing peroxidase from Thermomonospora curvata, ACS Catal. 2016, 6, 8036-8047, DOI: 10.1021/acscatal.6b01952.
  9. Jia, K., Cao, R., Hua, D.H., and Li, P.* Study of class I and class III polyhydroxyalkanoate (1xbet sports betting ) synthases with substrates containing a modified side chain, Biomacromolecules 2016, 17, 1477-1485, DOI: 10.1021/acs.biomac.6b00082.
  10. Chen, C., Shrestha, R., Jia, K., Gao, P.F., Geisbrecht, B.V., Bossmann, S. H., Shi, J., and Li, P.* Characterization of dye-decolorizing peroxidase (DyP) 1xbet sports betting Thermomonospora curvata reveals unique catalytic properties of A-type DyPs, J. Biol. Chem. 2015, 290, 23447-23463, DOI: 10.1074/jbc.M115.658807.
  11. Chen, C., Cao, R., Shrestha, R., Ward, C., Katz, B.B., Fischer, C.J., Tomich, J.M. and Li, P.* Trapping of intermediates with substrate analog HBOCoA in the polymerizations catalyzed by class III polyhydroxybutyrate (PHB) synthase 1xbet sports betting Allochromatium Vinosum, ACS Chem. Biol. 2015, 10, 1330-1339, DOI: 10.1021/cb5009958.
  12. Zhang, W., Chen, C., Cao, R., Maurmann, L., and Li, P.* Inhibitors to polyhydroxyalkanoate (1xbet sports betting ) synthases: synthesis, molecular docking, and implications, ChemBioChem 2015, 16, 156-166, DOI: 10.1002/cbic.201402380.
  13. Zhang, W., Shrestha, R., Buckley, R. M., Jewell, J., Bossmann, S. H., Stubbe, J., and Li, P.* Mechanistic insight with HBCH2CoA as a probe to polyhydroxybutyrate (PHB) synthases, ACS Chem. Biol. 2014, 9, 1773-1779, DOI: 10.1021/cb5002735.