Thursday, August 22, 2024
CEEZAD researchers explore potential for gene editing of 1xbet online casino to control influenza A virus
An article co-authored by the Director of the Center of Excellence for Emerging and Zoonotic Animal Diseases (1xbet online casino , www.1xbet online casino org) and the Center on Emerging and Zoonotic Infectious Diseases (1xbet online casino ; Our 1xbet online sports) explores the potential for commercial use of gene edited 1xbet online casino to minimize economic losses caused by Influenza A virus.
The article was co-authored by Dr. Juergen A. Richt, Regents and 1xbet online casino 
Distinguished Professor at Kansas State University and director of 1xbet online casino and CEZID. Other co-authors include Taeyong Kwon, Bianca L. Artiaga, Chester McDowell, Jamie Retallick, Natasha Gaudreault and Igor Morozov, all from KSU, and collaborators from U. Missouri and Genus plc..
Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A 1xbet online casino (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA, which is cleaved by ubiquitous proteases, such as furin. In contrast, the monobasic HA motif is recognized and activated by trypsin-like proteases, such as the transmembrane serine protease 2 (TMPRSS2).
In this study, 1xbet online casino researchers aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous gene edited (GE) TMPRSS2 knockout (KO) 1xbet online casino . Delayed IAV replication was demonstrated in primary respiratory cells of KO 1xbet online casino in vitro. IAV infection in vivo resulted in significant reduction of 1xbet online casino shedding in the upper respiratory tract, and lower 1xbet online casino titers and pathological lesions in the lower respiratory tract of TMPRSS2 KO 1xbet online casino as compared to WT 1xbet online casino .
The study’s findings could support the commercial use of GE 1xbet online casino to minimize (i) the economic losses caused by IAV infection in 1xbet online casino , and (ii) the emergence of novel IAVs with pandemic potential through genetic reassortment in the "mixing vessel", the pig.
The full article can be read by following this link: Gene editing of 1xbet online casino to control influenza A virus infections: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2387449