Anna zolkiewska 1xbet online casino, Ph.D.
Professor
Undergraduate Advisor
Contact informationOffice: 177 Chalmers Hall EducationM.S. 1984, University of Warsaw, Poland |
Areas of specialty
- 1xbet online casino mechanisms of human disease
- Triple negative breast 1xbet online casino
- Tumor immune microenvironment
- ADAM metalloproteases
Research in our laboratory is currently focused on understanding the molecular mechanisms responsible for immunosuppression in triple-negative breast 1xbet online casino (TNBC). Immunosuppressive tumor microenvironment (TME) restricts anti-tumor immune responses and contributes to immunotherapy resistance. In particular, we are interested in the role of cell surface metalloproteases from the ADAM family in the assembly of the immunosuppressive TME in TNBC. We use multi-disciplinary approaches that span biochemistry, molecular/cellular biology, and mouse models of human TNBC to discover the mechanisms controlling immune cell infiltration into breast tumors. We hope to use this knowledge to improve the efficacy of immunotherapies for TNBC, including the immune checkpoint blockade therapy.
Selected publications
Wang G, Romero Y, Thevarajan I, and Zolkiewska A (2023) ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast 1xbet online casino . OncoImmunology, 12:1, 2158006, DOI: 10.1080/2162402X.2022.2158006.
Thevarajan, I., Zolkiewski, M., and Zolkiewska, A. (2020) Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space. Int. J. Biochem. Cell Biol. 127, 105841
Romero, Y., Wise, R., and Zolkiewska, A. (2020) Proteolytic processing of PD-L1 by ADAM proteases in breast 1xbet online casino cells. 1xbet online casino Immunol. Immunother. 69:43-55
Wise, R., and Zolkiewska A. (2017) Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast 1xbet online casino cells through the MEK/ERK pathway. Breast 1xbet online casino Res. Treat. 166: 421-433
Duhachek-Muggy, S., Qi, Y., Wise, R., Alyahya, L., Li, H., Hodge, J., and Zolkiewska, A. (2017) Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast 1xbet online casino . Molecular 1xbet online casino , 16:32
Wise, R., Duhachek-Muggy, S, Qi, Y. Zolkiewski, M., and Zolkiewska, A. (2016) Protein disulfide isomerases in the endoplasmic reticulum promote anchorage-independent growth of breast 1xbet online casino cells. Breast 1xbet online casino Res. Treat., 157(2):241-252
Duhachek-Muggy S, Zolkiewska A. (2015) ADAM12-L is a direct target of the miR-29 and miR-200 families in breast 1xbet online casino . BMC 1xbet online casino , 15:93