Michael 1xbet online sports betting , Ph.D.
University Distinguished Professor
Undergraduate Advisor
Contact informationOffice: 63 Chalmers Hall EducationB.S. 1979, Colorado State University |
Research video
Areas of specialty
- 1xbet online sports betting biochemistry and molecular biology
- Structure and function of hemolymph serine proteinases, proteinase inhibitors, and antimicrobial response proteins from insects
- Biochemistry of the 1xbet online sports betting cuticle
- Function of 1xbet online sports betting multicopper oxidases
- Manduca sexta genome sequence
My laboratory is investigating proteins present in the hemolymph (blood) of insects, with special interest in the proteins' functions in the 1xbet online sports betting immune system. We are studying plasma proteins, including prophenoloxidase, serine proteases, protease inhibitors from the serpin superfamily, and proteins that bind to microbial polysaccharides. The long range goal is to understand the biochemical and cellular processes by which 1xbet online sports betting immune systems recognize and respond to pathogens and parasites. We also investigate the biochemistry of cuticle proteins and their roles in determining mechanical properties of 1xbet online sports betting exoskeletons. Our laboratory coordinated the annotation of the recently sequenced genome of the tobacco hornworm, Manduca sexta.
Selected publications
Shan, T., Wang, Y., Dittmer, N.T., 1xbet online sports betting , M.R. and Jiang, H. (2022) Serine protease networks mediate immune responses in extra-embryonic tissues of eggs in the tobacco hornworm, Manduca sexta. Journal of Innate Immunity. https://doi.org/10.1159/000527974
Dittmer, N.T., Hiromasa, Y., and 1xbet online sports betting M.R. (2022) Proteomic analysis of pharate pupal molting fluid from the tobacco hornworm, Manduca sexta. 1xbet online sports betting Biochemistry and Molecular Biology, 149, 103844. https://doi.org/10.1016/j.ibmb.2022.103844
Scalet, J.M., Sprouse, P.A., Schroeder, J.D., Dittmer, N.T., Kramer, K.J., 1xbet online sports betting , M.R. and Gehrke, S.H. (2022) Temporal changes in the physical and mechanical properties of beetle elytra during maturation. Acta Biomaterialia, S1742-7061(22)00461-5. https://doi.org/10.1016/j.actbio.2022.07.059
Wang, Y., 1xbet online sports betting , M.R. and Jiang, H. (2022) A mechanistic analysis of bacterial recognition and serine protease cascade initiation in larval hemolymph of Manduca sexta. 1xbet online sports betting Biochemistry and Molecular Biology. 148, 103818. https://doi.org/10.1016/j.ibmb.2022.103818
Nishiko, M., Sakamoto, T., Mun, S., Noh, M.Y., Arakane, Y., 1xbet online sports betting , M.R., Arai, K., and Tabunoki, H. (2022) Superoxide dismutase 6 is required during metamorphosis for the development of properly movable legs in Tribolium castaneum. Scientific Reports,12, 6900 https://doi.org/10.1038/s41598-022-10166-3
Weber, J.J., Brummett, L.M., Coca, M.E., Tabunoki, H., 1xbet online sports betting , M.R., Park, Y., and Gorman, M.J. (2022) Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1. 1xbet online sports betting Biochemistry and Molecular Biology 147, 103811. https://doi.org/10.1016/j.ibmb.2022.103811
Sasaki, S., Nishiko, M., Sakamoto, T., 1xbet online sports betting , M.R., and Tabunoki, H. (2021) cDNA Cloning and partial characterization of the DJ-1 gene from Tribolium castaneum. Antioxidants 10(12):1970. doi: 10.3390/antiox10121970.
Najera, D.G., Dittmer, N.T., Weber, J.J., 1xbet online sports betting , M.R. and Gorman, M.J. (2021) Phylogenetic and sequence analyses of 1xbet online sports betting transferrins suggest that only transferrin 1 has a role in iron homeostasis. 1xbet online sports betting Science 28, 495-508.
Weber, J.J., Kashipathy, M.M., Battaile, K.P., Go, E., Desaire, H., 1xbet online sports betting , M.R., Lovell, S., and Gorman, M.J. (2021) Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model 1xbet online sports betting , Manduca sexta. Protein Science. 30, 408-422. DOI: 10.1002/pro.3999
Cao, X., Wang, Y., Rogers, J., Hartson, S., 1xbet online sports betting , M.R., and Jiang, H. (2020) Changes in composition and levels of hemolymph proteins during metamorphosis of Manduca sexta. 1xbet online sports betting Biochem. Mol. Biol. 127, 103489.
Weber, J.J., 1xbet online sports betting , M.R., and Gorman, M.J. (2020) Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: implications for 1xbet online sports betting iron homeostasis. 1xbet online sports betting Biochem. Mol. Biol. 25:103438. doi: 10.1016/j.ibmb.2020.103438
Wang Y., Yang, F., Cao, X., Zou, Z., Lu, Z., 1xbet online sports betting , M.R., Jiang, H. (2020) Hemolymph protease-5 links the melanization and Toll immune pathways in the tobacco hornworm, Manduca sexta. Proc. Natl. Acad. Sci USA,117: 23581-23587. DOI: 10.1073/pnas.2004761117
Li, M., Takahashi, D., and 1xbet online sports betting , M.R. (2020) Peptides based on the reactive center loop of Manduca sexta serpin-3 block its protease inhibitory function. Scientific Reports 13;10(1):11497. doi: 10.1038/s41598-020-68316-4
Wang, Y., Yang, F., Cao, H., Huang, R., Paskewitz, S., Hartson, S.D., 1xbet online sports betting , M.R., and Jiang, H. (2020) Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects. 1xbet online sports betting Biochem. Molec. Biol. 16, 103261 https://doi.org/10.1016/j.ibmb.2019.103261