Brian 1xbet online sports betting , Ph.D.
University distinguished 1xbet online sports betting Professor
Undergraduate Advisor
Contact information
Office: 176 Chalmers Hall
Phone: 785-532-3154
Fax: 785-532-7278
E-mail: geisbrechtb@ksu.edu
Education
B.S. 1996, Saint Vincent College, Latrobe, PA
Ph.D. 2000, The Johns Hopkins University School of Medicine, Baltimore, MD.
Research video
Areas of specialty
- Innate Immunity
- Molecular Basis of Infectious Diseases and Host-Pathogen Interactions
- Structural Biology and Molecular Recognition
My laboratory is taking a multidisciplinary approach toward a better understanding of the events which lay the foundation for initiation and propagation of staphylococcal disease. The ultimate goals of this research program are two-fold. The first is to use a structure-based approach to expand our basic knowledge of the various host/pathogen interactions that occur between S. 1xbet online sports betting and human physiological systems. As multiple antibiotic-resistant strains of this pathogen have emerged and disseminated throughout the public and health care setting, the number of therapies that effectively combat S. 1xbet online sports betting infection has grown dangerously low. Consequently, if we are to provide sufficient measures against S. 1xbet online sports betting infection in the future, we need to further our basic understanding of this how it interacts with and defends itself against the human body. Our second goal is to capitalize upon the information obtained from analysis of these host/pathogen interactions toward developing new treatments for human inflammatory diseases. For example, it is now understood that the complement system lies at the heart of a wide-range of inflammatory and vascular disorders in humans. Because studies from the last decade have shown that S. 1xbet online sports betting is particularly adept at evading complement attack, we believe that naturally-occurring staphylococcal complement inhibitor proteins may be useful templates for new types of anti-inflammatory drugs. Other work has also shown that S. 1xbet online sports betting actively blocks a number of other disease-associated defense and repair processes, including coagulation, neutrophil transmigration, and angiogenesis. All of this suggests that important breakthroughs for treating a number of non-infectious human diseases may actually be found by studying the biology of this important pathogen.
Selected publications
1xbet online sports betting , Lambris JD, Gros P. Complement component C3: A structural perspective and potential therapeutic implications. Semin Immunol. 2022 Jun 24:101627. doi: 10.1016/j.smim.2022.101627. Epub ahead of print. PMID: 35760703.
Xu X, Lewis Marffy AL, Keightley A, McCarthy AJ, 1xbet online sports betting . Group B Streptococcus Surface Protein β: Structural Characterization of a Complement Factor H-Binding Motif and Its Contribution to Immune Evasion. J Immunol. 2022 Mar 1;208(5):1232-1247. doi: 10.4049/jimmunol.2101078. Epub 2022 Feb 2. PMID: 35110419; PMCID: PMC8881398.
Savitt AG, Manimala S, White T, Fandaros M, Yin W, Duan H, Xu X, 1xbet online sports betting , Rubenstein DA, Kaplan AP, Peerschke EI, Ghebrehiwet B. SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems. Front Immunol. 2021 Nov 12:767347. doi: 10.3389/fimmu.2021.767347. PMID: 34804054; PMCID: PMC8602850.
Xu X, Zhang C, Denton DT, O'Connell D, Drolet DW, 1xbet online sports betting . Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. J Immunol. 2021 Feb 15;206(4):861-873. doi: 10.4049/jimmunol.2001260. Epub 2021 Jan 8. PMID: 33419768; PMCID: PMC7851746.
Herdendorf TJ, Stapels DAC, Rooijakkers SHM, 1xbet online sports betting . Local structural plasticity of the Staphylococcus 1xbet online sports betting evasion protein EapH1 enables engagement with multiple neutrophil serine proteases. J Biol Chem. 2020 May 29;295(22):7753-7762. doi: 10.1074/jbc.RA120.013601. Epub 2020 Apr 17. PMID: 32303641; PMCID: PMC7261791.
Peerschke EI, Stanchina E, Chang Q, Manova-Todorova K, Barlas A, Savitt AG, 1xbet online sports betting , Ghebrehiwet B. Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer. Antibodies (Basel). 2020 Oct 6;9(4):51. doi: 10.3390/antib9040051. PMID: 33036212; PMCID: PMC7709104.
Herdendorf TJ, 1xbet online sports betting . Staphylococcus 1xbet online sports betting evasion proteins EapH1 and EapH2: Residue-level investigation of an alternative binding motif for human neutrophil elastase. Arch Biochem Biophys. 2019 Nov 15;676:108140. doi: 10.1016/j.abb.2019.108140. Epub 2019 Oct 14. PMID: 31622584; PMCID: PMC6938032.
Mastellos DC, Blom AM, Connolly ES, Daha MR, 1xbet online sports betting , Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD. 'Stealth' corporate innovation: an emerging threat for therapeutic drug development. Nat Immunol. 2019 Nov;20(11):1409-1413. doi: 10.1038/s41590-019-0503-1. Erratum in: Nat Immunol. 2019 Oct 11;: PMID: 31562490; PMCID: PMC7368001.
Ghebrehiwet B, 1xbet online sports betting , Xu X, Savitt AG, Peerschke EIB. The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1). Semin Immunol. 2019 Oct;45:101338. doi: 10.1016/j.smim.2019.101338. Epub 2019 Nov 16. PMID: 31744753.
Herdendorf TJ, 1xbet online sports betting . Investigation of Human Neutrophil Elastase Inhibition by Staphylococcus 1xbet online sports betting EapH1: The Key Role Played by Arginine 89. Biochemistry. 2018 Dec 18;57(50):6888-6896. doi: 10.1021/acs.biochem.8b01134. Epub 2018 Nov 30. PubMed PMID: 30461258; PMCID: PMC6347974.
Ploscariu NT, de Jong NWM, van Kessel KPM, van Strijp JAG, 1xbet online sports betting . Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini. Arch Biochem Biophys. 2018 May 1;645:1-11. doi: 10.1016/j.abb.2018.03.007. Epub 2018 Mar 7. PubMed PMID: 29524428; PMCID: PMC5899673.
de Jong NWM, Vrieling M, Garcia BL, Koop G, Brettmann M, Aerts PC, Ruyken M, van Strijp JAG, Holmes M, Harrison EM, 1xbet online sports betting , Rooijakkers SHM. Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus 1xbet online sports betting strains. J Biol Chem. 2018 Mar 23;293(12):4468-4477. doi: 10.1074/jbc.RA117.000599. Epub 2018 Feb 5. PubMed PMID: 29414776; PMCID: PMC5868266.
de Jong NWM, Ploscariu NT, Ramyar KX, Garcia BL, Herrera AI, Prakash O, Katz BB, Leidal KG, Nauseef WM, van Kessel KPM, van Strijp JAG, 1xbet online sports betting . A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN). J Biol Chem. 2018 Feb 16;293(7):2260-2271. doi: 10.1074/jbc.RA117.000134. Epub 2018 Jan 5. PubMed PMID: 29306874; PMCID: PMC5818189.
Stapels DAC, Woehl JL, Milder FJ, Tromp AT, van Batenburg AA, de Graaf WC, Broll SC, White NM, Rooijakkers SHM, 1xbet online sports betting . Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins. Protein Sci. 2018 Feb;27(2):509-522. doi: 10.1002/pro.3342. Epub 2017 Nov 21. PubMed PMID: 29114958; PMCID: PMC5775164.
de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, 1xbet online sports betting , Haas PA. Immune evasion by a staphylococcal inhibitor of myeloperoxidase. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9439-9444. doi: 10.1073/pnas.1707032114. Epub 2017 Aug 14. PMID: 28808028; PMCID: PMC5584439.