Maureen 1xbet best casino website , Ph.D.
Research Associate Professor
Contact informationOffice: 64 Chalmers Hall EducationB.S. 1984, University of Notre Dame |
Areas of specialty
- 1xbet best casino website biochemistry, molecular biology and genetics
- Mechanisms of iron metabolism in insects
- Function of 1xbet best casino website multicopper oxidases
- 1xbet best casino website innate immunity
Iron metabolism is a vital biological process in all eukaryotic organisms, but the mechanisms of iron metabolism in insects are poorly understood. Our research is focused on iron transport and the relationship between iron metabolism and innate immunity in insects. We use a combination of genetics, molecular biology, and biochemistry methods to study iron metabolism in Drosophila melanogaster (fruit fly) and Manduca sexta (tobacco hornworm). Our current research is focused on transferrin and ferritin, two iron-binding proteins in 1xbet best casino website blood, and on two ferric reductases that are located in 1xbet best casino website cell membranes. One potential long term outcome of this research program is a better understanding of how to manage beneficial and destructive insects.
Selected publications
Weber, J.J., Geisbrecht, B.V., Kanost, M.R., 1xbet best casino website , M.J. (2024) A conserved asparagine residue stabilizes iron binding in Manduca sexta transferrin-1. 1xbet best casino website Biochemistry and Molecular Biology 168: 104109. doi.org/10.1016/j.ibmb.2024.104109.
1xbet best casino website , M.J. (2023) Iron homeostasis in insects. Annual Review of Entomology 68: 51-67. doi.org/10.1146/annurev-ento-040622-092836.
Weber, J.J., Brummett, L.M., Coca, M.E., Tabunoki, H., Kanost, M.R., Ragan, E.J., Park, Y., and 1xbet best casino website , M.J. (2022) Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1. 1xbet best casino website Biochemistry and Molecular Biology 147: 103811. doi: 10.1016/j.ibmb.2022.103811.
Weber, J.J., Kashipathy, M.M., Battaile, K.P., Go, E., Desaire, H., Kanost, M.R., Lovell, S., and 1xbet best casino website , M.J. (2020) Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model 1xbet best casino website , Manduca sexta. Protein Science, Nov 16. doi: 10.1002/pro.3999.
Weber, J.J., Kanost M.R., and 1xbet best casino website , M.J. (2020) Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: implications for 1xbet best casino website iron homeostasis. 1xbet best casino website Biochemistry and Molecular Biology 125: 103438. doi: 10.1016/j.ibmb.2020.103438.
Najera, D.G, Dittmer, N.T., Weber, J.J., Kanost, M.R., and 1xbet best casino website , M.J. (2020) Phylogenetic and sequence analyses of 1xbet best casino website transferrins suggest that only transferrin 1 has a role in iron homeostasis. 1xbet best casino website Science, Mar 31;. doi: 10.1111/1744-7917.12783.
Brummett, L.M., Kanost, M.R., and 1xbet best casino website , M.J. (2017) The immune properties of Manduca sexta transferrin. 1xbet best casino website Biochemistry and Molecular Biology 81: 1-9.
Peng, Z., Dittmer N.T., Lang, M., Brummett, L.M., Braun, C.L., Davis, L.C., Kanost, M.R., and 1xbet best casino website , M.J. (2015) Multicopper oxidase-1 orthologs from diverse 1xbet best casino website species have ascorbate oxidase activity. 1xbet best casino website Biochemistry and Molecular Biology 59: 58-71.
Peng, Z., Green, P.G., Arakane, Y., Kanost, M.R., and 1xbet best casino website , M.J. (2014) A multicopper oxidase-related protein is essential for 1xbet best casino website viability, longevity and ovary development. PloS ONE 9: e111344.
Lang, M., Braun, C.L., Kanost, M.R., and 1xbet best casino website , M.J. (2012) Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. Proceedings of the National Academy of Sciences, USA doi: 10.1073/pnas.1208703109.
Lang, M., Kanost, M.R., and 1xbet best casino website , M.J. (2012) Multicopper oxidase-3 is a laccase associated with the peritrophic matrix of Anopheles gambiae. PLoS One 7: e33985.
1xbet best casino website , M.J., Sullivan, L.I., Nguyen, T.D.T., Dai, H., Arakane, Y., Dittmer, N.T., Syed, L.U., Li, J., Hua, D.H., and Kanost, M.R. (2012) Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae. 1xbet best casino website Biochemistry and Molecular Biology 42: 193-202.
1xbet best casino website , M.J., and Arakane, Y. (2010) Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in Tribolium castaneum. 1xbet best casino website Biochemistry and Molecular Biology 40: 267-273.