Bradley J.S.C. Olson, Associate Professor
Contact information
239E Chalmers Hall
(785) 532-6149
bjsco@k-state.edu
Lab website: https://1xbet online sports betting org/
Education
Ph.D., 2008,Michigan State University. Biochemistry and Molecular Biology.
Area(s) of Specialization
Molecular and ecological basis of 1xbet online sports betting evolution.
Research Focus
My long-term research interest is to understand the molecular and ecological basis of major evolutionary state transitions. The primary question my laboratory investigates is how did 1xbet online sports betting organisms evolve? 1xbet online sports betting organisms are those we most commonly perceive in our “macro” environment, yet little is known about the molecular and ecological basis of 1xbet online sports betting evolution unknown.
Well known member species include the unicellular algaeChlamydomas reinhardtiiandVolvox carteri.
The morphological and evolutionary progression of the volvocales suggests stepwise 1xbet online sports betting of multicellularity, starting with colony formation between unicells (e.g.Gonium), then a stepwise progression of cell expansion, division of labor, specialization and tissue differentiation (e.g.Volvox). Despite their morphological differences, the genomes ofChlamydomonasandVolvoxare remarkably similar, suggesting that multicellularity requires few genetic changes.
My laboratory is utilizing two key approaches for understanding the molecular basis of 1xbet online sports betting evolution. First, my laboratory is leading a consortium to sequence the genomes and determine the developmental transcriptional profiles of several key volvocales. Second, my laboratory is using a systems biology approach toward determining which genes are important for all steps of multicellularity. My laboratory is particularly interested in understanding how and why individual unicells formed groups of cooperative cells, termed colonialism. To do this we are focusing onGonium as a model for colonial evolution.
Understanding how and why individual cells evolved into 1xbet online sports betting organisms is an important evolutionary question and is important for our understanding of how human bodies maintain organizational control over cells. For example, human cancer is a fundamental loss of control of the growth and division of cells within the tissues of the body. Many of the genes defective in human cancers have been identified, however little is known about how 1xbet online sports betting organisms evolved control over their individual constituent cells. Long term, research in my laboratory is aimed at understanding how organisms evolved regulatory pathways controlling cell growth, division, and differentiation so that new approaches to cancer treatment could be developed.
Selected Publications
Olson,B.J.S.C., M. Olberholzer, Y. Li, J.M. Zones, H..S Kohli, K. Bisova, J. Meisenhelder, T. Hunter, and .JG. Umen. 2010.Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex.The Plant Cell22(10):3331-47.
Olson, B.J.S.C.,Q. Wang, and K.W. Osteryoung. 2010.GTP-dependent heteropolymer formation and bundling of chloroplast FtsZ1 and FtsZ2.The Journal of Biological Chemistry. 285(27): 20634-20643.
Ferris, P., B.J.S.C. Olson, P. de Hoff, S. Douglass, D. Diaz-Cano, S. Prochnik, S. Geng, R. Rai, J. Grimwood, J. Schmutz, I. Nishii, T. Hamaji, H. Nozaki, M. Pellegrini, and J.G. Umen. 2010.1xbet online sports betting of an expanded sexdetermining locus in Volvox.Science. 328: 351-4.
Schmitz,A.J., J.M. Glynn, B.J.S.C. Olson, K.D. Stokes, K.W. Osteryoung. 2009.Arabidopsis FtsZ2-1 and FtsZ2-2 are functionally redundant, but FtsZ-Based plastid 1xbet online sports betting is not essential for chloroplast partitioning or plant growth and development.Molecular Plant. 2(6): 1211-22.
McAndrew,R.S., B.J.S.C. Olson, D. Kadirjan-Kalbach, C.H. Chi-Ham, J.E. Froelich, and .KW. Osteryoung. 2008.In vivo quantitative relationship between plastid 1xbet online sports betting proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.Biochemical Journal412: 367–378.
Yoder, D.W., D. Kadirjan-Kalbach, B.J.S.C. Olson, S. Miyagishima, S. DeBlasio, R. Hangarter, and K.W. Osteryoung. 2007.Effects of mutations in Arabidopsis FtsZ1 on plastid 1xbet online sports betting , FtsZ ring formation and positioning, and FtsZ filament morphology in vivo.Plant and Cell Physiology48(6): 775-791.
Olson,B.J.S.C., M. Skavdahl, H. Ramberg, J.C. Osterman, and J. Markwell. 2000.Formate Dehydrogenase in Arabidopsis thalina: Characterization and possible targeting to the chloroplast.Plant Science160(2): 205- 212.
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