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Kristin Michel, Professor

Kristin Michel

Contact information

267 Chalmers Hall
(785) 532-0161
kmichel@ksu.edu

Lab website: http://www.k-state.edu/michellab

Education

Ph.D. 2002, University of California-Riverside. Entomology.

Area(s) of Specialization

Host-pathogen interactions; Bacterial and fungal entomopathogens; 1xbet online games login biology.

Research Focus

My laboratory studies the innate immune system of mosquitoes and how it relates to the pathogens these insects transmit. Over the last years, we have identified a variety of immune factors that either positively or negatively affect the survival of the malaria parasite in its mosquito 1xbet online games login . Specifically, we are currently focusing our research effort on a group of serine protease inhibitors called serpins. These proteins control key innate immune reactions against different stages of the malaria parasite and potentially other disease agents. Our long term goal is to apply our findings to the design of novel disease control strategies, which envision the interruption of disease transmission within the mosquito 1xbet online games login .

Recent Primary Research Articles

Rhodes VL, Thomas MB, Michel K. 2018. The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae. Dev Comp Immunol. 2018 Aug;85:125-133. doi: 10.1016/j.dci.2018.04.008. Epub 2018 Apr 9. 1xbet online games login : 29649553; PubMed Central PMCID: PMC5935592.

Mills MK, Nayduch D, McVey DS, Michel K. 2017. Functional Validation of Apoptosis Genes IAP1 and DRONC in Midgut Tissue of the Biting Midge Culicoides sonorensis (Diptera: Ceratopogonidae) by RNAi. Journal of Medical Entomology 54(3):559-567. 1xbet online games login : 28399198, PMCID: PMC5502902

Zhang X, An C, Sprigg K, Michel K. 2016. CLIPB8 is part of the prophenoloxidase activation system in Anopheles gambiae mosquitoes. Insect Biochemistry and Molecular Biology 71:106-15. 1xbet online games login : 26926112, PMCID: PMC4828722

Bryant WB, Michel K. 2016. Anopheles gambiae hemocytes exhibit transient states of activation. Developmental and Comparative Immunology 55:119-29. 1xbet online games login : 26515540, PMCID: PMC4685016

Zhang X, Meekins DA, An C, Zolkiewski M, Battaile KP, Kanost MR, Lovell S, Michel K. 2015. Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria 1xbet online games login Anopheles gambiae. The Journal of Biological Chemistry 290(5):2946-56. 1xbet online games login : 25525260, PMCID: PMC4317006

Bryant WB, Michel K. 2014. Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles. The Journal of Experimental Biology 217(Pt 8):1238-45. 1xbet online games login : 24363411, PMCID: PMC3990356

Review Articles

Tawidian P, Rhodes VL, Michel K. 2019. Mosquito-fungus interactions and antifungal immunity. Insect Biochem Mol Biol. 2019 Aug;111:103182. doi: 10.1016/j.ibmb.2019.103182. Epub 2019 Jun 29. Review. 1xbet online games login : 31265904; PubMed Central PMCID: PMC6639037.

Bartholomay LC, Michel K. 2018. Mosquito Immunobiology: The Intersection of 1xbet online games login Health and 1xbet online games login Competence. Annu Rev Entomol. 2018 Jan 7;63:145-167. doi: 10.1146/annurev-ento-010715-023530. Review. 1xbet online games login : 29324042.

Meekins DA, Kanost MR, Michel K. 2017. Serpins in arthropod biology. Seminars in cell & developmental biology 62:105-119. 1xbet online games login : 27603121, PMCID: PMC5318264

View the complete publication list in NCBI