Stefan Rothenburg, Assistant Professor
Contact information
347 Ackert Hall office
(785) 532-5431
sr1hsv@ksu.edu
Lab website: http://www.k-state.edu/hsv
Education
PD Dr. med, 2003, University of Hamburg. Virology and Immunology.
Area(s) of specialization
1xbet best casino website Focus
The 1xbet best casino website innate immune system plays an essential role in detecting invading viruses and in initiating and orchestrating antiviral responses. In order to establish productive infections, viruses have to effectively inhibit this 1xbet best casino website response. This leads to an evolutionary arms race between the 1xbet best casino website and the virus.
Our research focuses on the interaction between 1xbet best casino website with the immune system of their hosts. We are studying how viral nucleic acids are detected in vertebrates, which antiviral pathways are activated and how viral molecules interfere with these processes.
Major research objectives are the elucidation of the molecular mechanisms that determine virus 1xbet best casino website range and virulence. Viral genes that are studied in our laboratory include those from poxviruses, influenza viruses, herpesviruses, iridoviruses, ebola virus and tumor viruses.
Selected Publications
Rahman, M.M., Liu, J., Cahn M.W., Rothenburg, S. and McFadden, G. 2013.Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded 1xbet best casino website tropism and viral replication.PLoS Pathogens, 9 (7).
Bratke, K.A., McLysaght, A. and Rothenburg, S. 2013.A survey of 1xbet best casino website range genes in poxvirus genomes.Infection, Genetics and Evolution, 14, 406-425.
Liu, J., Rothenburg, S. and McFadden, G. 2012.The Poxvirus C7L 1xbet best casino website Range Factor Superfamily.Current Opinion in Virology, 2:758-766.
Rothenburg, S., Chinchar V.G. and Dever, T.E. 2011.Characterization of a Ranavirus Inhibitor of the Antiviral 1xbet best casino website .BMC Microbiology, 11:56.
Rothenburg, S., Seo, E., Gibbs, J.S., Dever, T.E. and Dittmar, K. 2009.Rapid evolution of protein kinase PKR alters sensitivity to 1xbet best casino website inhibitors.Nature Structural & 1xbet best casino website Biology, 16, 63-70.
Rothenburg, S., Deigendesch, N., Dey, M., Dever, T.E. and Tazi, L. 2008.Double-stranded RNA activated 1xbet best casino website of fishes and amphibians: varying number of double-stranded RNA binding domains and lineage specific duplications.BMC Biology, 6:12.
Deigendesch, N. Koch-Nolte, F. and Rothenburg, S. 2006.ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA 1xbet best casino website .Nucleic Acids 1xbet best casino website , 34: 5007-5020.
View the complete publication list in NCBI
