Katsura 1xbet online casino , Professor
Contact information
258 Chalmers Hall
(785) 532-0116
kasano@ksu.edu
Education
Ph.D. 1994, University of Tokyo, Japan.
Area(s) of Specialization
1xbet online casino of protein biosynthesis
Yeast 1xbet online casino and biochemistry
1xbet online casino and cell biology of insects and cancer
Research Focus
Our long-term goal is to understand the mechanism and control of eukaryotic 1xbet online casino at the molecular level. 1xbet online casino is the rate-limiting step of protein biosynthesis and an important target for the control of gene expression. Unregulated 1xbet online casino is an important phenotype of malignantly transformed cells. We are particularly interested in the biological effects of translational regulation by altering the choice of start codons, including non-AUG start codons.
The main player of our projects is translation initiation multifactor complex (MFC), a ~1 MDa complex made of eukaryotic initiation factors (1xbet online casino ) 1, 2, 3, 5 and the initiator Met-tRNA. This is found in all the eukaryotic species examined so far including humans and yeasts. MFC allows stringent translation initiation at AUG codons and serves as the platform of complex translational regulation required for higher-ordered eukaryotic functions. We dissect MFC functions by genetics using mutations in two proteins, eIF3e/Int-6 and eIF5-mimic protein (5MP). Being located in the structural core of eIF3, eIF3e plays an important role in translational regulation, coordinating cellular proliferation and metabolism. As a molecular mimic and competitor of eIF5, 5MP inhibits MFC function, regulating initiator Met-tRNA recruitment to the ribosome and stringency of translation initiation. We use yeasts, insects, and human cells, including cancer cells, to study MFC functions in stringent translation initiation, cell differentiation, and neuronal growth regulation.
Selected Publications
Chingakham Ranjit Singh, Marry Rebecca Glineburg, Chelsea Moore, Naoki Tani, Rahul Jaiswal, Ye Zou, Eric Aube, Sarah Gillaspie, Mackenzie Thornton, Ariana Cecil, Madelyn Hilgers, Azuma Takasu, Izumi 1xbet online casino , Masayo 1xbet online casino , Carlos R. Escalante, Akira Nakamura, Peter Todd, and Katsura 1xbet online casino . 2021. Human oncoprotein 5MP suppresses general and repeat-associated non-AUG 1xbet online casino via eIF3 by a common mechanism. 1xbet online casino Reports 36, 103976.
Yuji Chikashige, Hiroaki Kato, Mackenzie Thornton, Whitney Pepper, Madelyn Hilgers, Ariana Cecil, Izumi 1xbet online casino , Haana Yamada, Chie Mori, Cheyenne Brunkow, Carter Moravek, Takeshi Urano, Chingakham Ranjit Singh, and Katsura 1xbet online casino . 2020. Gcn2 eIF2a kinase mediates combinatorial 1xbet online casino through nucleotide motifs and uORFs in target mRNAs. Nucl. Acids Res. 48(16):8977-8992.
Kuniaki Sato, Takaaki Masuda, Qingjiang Hu, Taro Tobo, Sarah Gillaspie, Atsushi Niida, Mackenzie Thornton, Yousuke Kuroda, Hidetoshi Eguchi, Takashi Nakagawa, Katsura 1xbet online casino , and Koshi Mimori. 2019. Novel oncogene 5MP1 reprograms c-myc 1xbet online casino to drive malignant phenotypes in colorectal cancer. EBioMedicine 44, 387-402.
Leiming Tang, Jacob Morris, Ji Wan, Chelsea Moore, Yoshihiko Fujita, Sarah Gillaspie, Eric Aube, Jagpreet Nanda, Abbey Anderson, Christian Cox, Hiroyuki Hiraishi, Leiming Dong, Maud Marques, Maika Jangal, Chingakham Ranjit Singh, Hirohide Saito, Michael Witcher, Ivan Topisirovic, Shu-Bing Qian, Katsura 1xbet online casino . 2017. Competition between 1xbet online casino factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide. Nucl Acids Res45(20):11941-11953.
Eiji Obayashi, Rafael E. Luna, Takashi Nagata, Pilar Martin-Marcos, Hiroyuki Hiraishi, Chingakham Ranjit Singh, Jan Peter Erzberger, Fan Zhang, Haribabu Arthanari, Jacob Morris, Riccardo Pellarin, Chelsea Moore, Ian Harmon, Evangelos Papadopoulos, Hisashi Yoshida, Mahmoud L. Nasr, Satoru Unzai, Brytteny Thompson, Eric Aube, Samantha Hustak, Florian Stengel, Eddie Dagraca, Asokan Ananbandam, Philip Gao, Takeshi Urano, Alan G. Hinnebusch, Gerhard Wagner, and Katsura 1xbet online casino . 2017. Molecular landscape of the ribosome pre-1xbet online casino complex during mRNA scanning: structural role for eIF3c and its control by eIF5. 1xbet online casino Reports 18(11):2651-2663.
Caitlin Kozel, Brytteny Thompson, Samantha Hustak, Chelsea Moore, Akio Nakashima, Chingakham Ranjit Singh, Megan Reid, Christian Cox, Evangelos Papadopoulos, Rafael E. Luna, Abbey Anderson, Hideaki Tagami, Hiroyuki Hiraishi, Emily Archer Slone, Ken-ichi Yoshino, Masayo 1xbet online casino , Sarah Gillaspie, Jerome Nietfeld, Jean-Pierre Perchellet, Stefan Rothenburg, Hisao Masai, Gerhard Wagner, Alexander Beeser, Ushio Kikkawa, Sherry D. Fleming, and Katsura 1xbet online casino . 2016. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 1xbet online casino through delayed re-initiation. Nucl Acids Res 44(18):8704-8713.
Katsura 1xbet online casino . 2021. Origin of 1xbet online casino control by eIF2α phosphorylation: Insights from genome-wide 1xbet online casino profiling studies in fission yeast. Current 1xbet online casino , published online 09 Jan 2021.
1xbet online casino , K. 2014. Why is start codon selection so precise in eukaryotes? Review. 1xbet online casino 2, e28387.
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