Kathrin 1xbet sports betting , Associate Professor

Contact information

303 Ackert Hall
(785) 532-6360
kschrick@ksu.edu

Lab website: http://www.k-state.edu/schricklab

Education

Ph.D. 1994, University of Washington. Genetics.

Area(s) of Specialization

1xbet sports betting Molecular Biology, Developmental Biology, 1xbet sports betting Evolution, START Domains, 1xbet sports betting Sterols.

Research Focus

Plants and 1xbet sports betting -derived products such as food, fiber, fuel, and medicines, are vital to life on earth. Many of these resources rely on 1xbet sports betting -specific biochemical reactions involving proteins and lipid metabolites. Direct interactions between proteins and small molecules are dynamic in all living cells, yet their full extent and biological significance is underexplored, especially in plants. We use genetics and molecular approaches in the model system Arabidopsis to study protein-metabolite interactions involving sterols and other metabolic lipids in the context of 1xbet sports betting growth and development.

START domains in plants

Candidate lipid/sterol-binding proteins include transcription factors of the class III and IV homeodomain leucine-zipper (HD-Zip) family. These 1xbet sports betting -specific regulatory proteins contain a StAR-related lipid transfer (START) domain, named after mammalian steroidogenic acute regulatory protein orthologs (StARs). In humans, misexpression of several START domain proteins is associated with cancer. It is hypothesized that START domains link lipid/sterol metabolism to the cell division cycle. We are studying the role of START domains in class IV HD-Zip transcription factors that are critical for differentiation of the epidermis. Related to this, we are investigating relevant evolutionary mechanisms that led to the emergence of the land plants from the Charophycean green algae ~450 million years ago.

Sterols in development and in cell wall biogenesis

Another research focus is on the functions of sterols and their glycosylated forms in plants. Sterol biosynthesis enzymes are differentially expressed throughout development and sterol contents vary temporally and spatially according to cell type. Sterol production may reflect the metabolic state of cells, which in turn is exploited to regulate developmental processes. Sterols are also important as structural features of cell membranes. Our discovery that sterol biosynthesis is crucial for cellulose production suggests a mechanism by which sterols influence cell wall biogenesis. One proposed model suggests that glycosylated sterols act as primers in cellulose synthesis, by supplying glucose residues to growing microfibrils. We are characterizing UDP-glucose:sterol glucosyltransferase mutants of Arabidopsis to address this hypothesis. If specific steryl glucosides and/or sterols are critical for cellulose synthesis, their modulation may yield improved cellulose production in biomass crops.

Selected Publications

Wojciechowska, I., Mukherjee, T., Knox-Brown, P., Hu, X., Khosla, A., Subedi, B., Ahmad, B., Mathews, G.L., Panagakis, A.A., Thompson, K.A., Peery, S.T., Szlachetko, J., Thalhammer, A., Hincha, D.K., Skirycz, A., 1xbet sports betting , K. 2024. Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism. New Phytol. (published online 7-2-2024). doi:10:1111/nph.19917

1xbet sports betting , K., Ahmad, B., and Nguyen, H.V. 2023. HD-Zip IV transcription factors: Drivers of epidermal cell fate integrate metabolic signals. Curr Opin 1xbet sports betting Biol. 75:e102407. doi: 10.1016/j.pbi.2023.102417

Lusk, H.J., Neumann, N., Colter, M., Roth, M.R., Tamura, P, Yao, L., Shiva, S., Shah, J, 1xbet sports betting , K., Durrett, T., and Welti, R. 2022. Lipidomic analysis of Arabidopsis T-DNA insertion lines leads to identification and characterizationof C-terminal alterations in FATTY ACID DESATURASE 6. 1xbet sports betting Cell Physiol: pcac088. doi: 10.1093/pcp/pcac088

Mukherjee, T., Subedi, B., Khosla, A., Begler, E.M., Stephens, P.M., Warner, A.L., Lerma-Reyes, R., Thompson, K.A., Gunewardena, S., and 1xbet sports betting , K. 2022. The START domain mediates Arabidopsis GLABRA2 dimerization and turnover independently of homeodomain DNA binding. 1xbet sports betting Physiol. (published online 8-19-2022). doi: 10.1093/plphys/kiac383

Subedi, B., and 1xbet sports betting , K. 2022. EYFP fusions to HD-Zip IV transcription factors enhance their stability and lead to phenotypic changes in Arabidopsis. 1xbet sports betting Signal Behav. 17(1):e2119013. doi: 10.1080/15592324.2022.2119013

Shiva, S., Samarakoon, T., Lowe, K.A., Roach, C., Vu, H.S., Colter, M., Porras, H., Hwang, C., Roth, M.R., Tamura, P., Li, M., 1xbet sports betting , K., Shah, J., Wang, X, Wang, H., and Welti, R. 2020. Leaf lipid alterations in response to heat stress of Arabidopsis thaliana. Plants 9(7): 10.3390/plants9070845.

Velazhahan, V., Glaza, P., Herrera, A.I., Prakash, O., Zolkiewski, M., Geisbrecht, B.V., and 1xbet sports betting , K. 2020. Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53. PLOS One 15:e0234468. doi:10.1371/journal.pone.0234468.

Mukherjee., T., Lerma-Reyes, R., Thompson, K.A., and 1xbet sports betting , K. 2019. Making glue from seeds and gums: Working with 1xbet sports betting -based polymers to introduce students to 1xbet sports betting biochemistry. Biochem Mol Biol Educ 47:468-475. doi:10.1002/bmb.21252.

Paper, J.M., Mukherjee, T., and 1xbet sports betting , K. 2018. Bioorthogonal click chemistry for fluorescence imaging of choline phospholipids in plants. 1xbet sports betting Methods 14:31.

Pook, V.G., Nair, M., Ryu, K., Arpin, J.C., Schiefelbein, J., 1xbet sports betting , K., and DeBolt, S. 2017. Positioning of the SCRAMBLED receptor requires UDP-Glc:sterol glucosyltransferase 80B1 in Arabidopsis roots. Sci Rep. 7(1): 5714.

Msanne, J., Chen, M., Luttgeharm, K., Bradley, A.M., Mays, E.S., Paper, J.M., Boyle, D.L., Cahoon, R.E., 1xbet sports betting , K., and Cahoon, E.B. 2015. Glucosylceramide is critical for cell-type differentiation and organogenesis, but not for cell viability in Arabidopsis . 1xbet sports betting J. 84:188-201.

Stucky, D.F., Arpin, J.C., and 1xbet sports betting , K. 2015. Functional diversification of two UGT80 enzymes required for steryl glucoside synthesis in Arabidopsis . J. Exp. Bot. 66:189-201.

1xbet sports betting , K., Bruno, M., Khosla, A., Cox, P.N., Marlatt, S.A., Roque, R.A., Nguyen, H.C., He, C., Snyder, M.P., Singh, D., and Yadav, G. 2014. Shared functions of 1xbet sports betting and mammalian StAR-related lipid transfer (START) domains in modulating transcription factor activity. BMC Biology 12:70. doi:10.1186/s12915-014-0070-8.

Khosla, A., Paper, J.M., Boehler, A.P., Bradley, A.M., Neumann, T.R., and 1xbet sports betting , K. 2014. HD-Zip proteins GL2 and HDG11 have redundant functions in Arabidopsis trichomes and Gl2 activates a positive feedback loop via MYB23. 1xbet sports betting Cell 26:2184-2200.​

1xbet sports betting , K., DeBolt, S., and Bulone, V. 2012. Deciphering the molecular functions of sterols in cellulose biosynthesis. Front. 1xbet sports betting Sci. 3:84. doi: 10.3389/fpls.2012.00084

1xbet sports betting , K., Shiva, S., Arpin, J.C., Delimont, N., Isaac, G., Tamura, P. and Welti, R. 2012. Steryl glucoside and acyl steryl glucoside analysis of Arabidopsis seeds by electrospray ionization tandem mass spectrometry. Lipids 47:185-193.

1xbet sports betting , K., Cordova, C., Li, G., Murray, L. and Fujioka, S. 2011. A dynamic role for sterols in embryogenesis of Pisum sativum. Phytochemistry 72: 465-475.

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