Jocelyn 1xbet online sports betting , Associate Professor
Contact information
239B Chalmers Hall
jmcdona@ksu.edu
1xbet online sports betting website: http://mcdonaldlab.org/
Education
Ph.D. 1998, University of Illinois, Urbana-Champaign. 1xbet online sports betting and Developmental Biology.
Area(s) of Specialization
Developmental and 1xbet online sports betting biology; 1xbet online sports betting migration; tissue morphogenesis.
Research Focus
The overall interest of my laboratory is to understand how 1xbet online sports betting migration is regulated within the normal three-dimensional environment of tissues. We are particularly interested in a type of migration called "collective" migration, in which small to large groups of cells coordinate and move together. Cells move collectively during normal physiological processes, such as during embryonic development and wound healing, whereas abnormal collective migration contributes to birth defects, tumor metastasis in cancer, failure of wounds to heal, and other disease pathologies. Therefore, it is of fundamental medical importance to identify the genetic, cellular, and molecular mechanisms that control this type of 1xbet online sports betting movement.
My laboratory primarily uses border cells, a model of collective 1xbet online sports betting migration in tissues. These six to 10 cells move as a cohesive group during development of the ovary in the model organism Drosophila melanogaster (the fruit fly). The variety of sophisticated genetic and molecular tools in Drosophila allow us to identify new genes that control movement of border cells. Many of these genes have counterparts in humans, and the ultimate goal of the lab is to determine whether the genes identified in Drosophila also regulate human 1xbet online sports betting migration in pathological contexts.
We use a combination of live imaging, genetics and 1xbet online sports betting biological approaches to uncover mechanisms that control multicellular collective 1xbet online sports betting migration. Ongoing interests in the lab include: how groups of cells break away from epithelia to become migratory; how individual cells adhere together and become coordinated to produce group movement; and interplay of 1xbet online sports betting polarity and cytoskeletal regulatory proteins in collective migration. Finally, we have an ongoing collaboration with investigators at the Cleveland Clinic to apply our findings in the Drosophila border 1xbet online sports betting model to tumor invasion, particularly in glioblastoma.
Selected Publications
Chen Y, 1xbet online sports betting . 2024 . Collective 1xbet online sports betting migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response. Curr Biol. 2024 Apr 8;34(7):1390-1402.e4. doi: 10.1016/j.cub.2024.02.014. Epub 2024 Feb 29. PMID: 38428416
Burghardt E, Rakijas J, Tyagi A, Majumder P, Olson BJSC, 1xbet online sports betting . 2023. Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border 1xbet online sports betting collective migration. BMC Genomics. 2023 Dec 1;24(1):728. doi: 10.1186/s12864-023-09839-8. PMID: 38041052.
Messer CL, 1xbet online sports betting . 2023. Rap1 promotes epithelial integrity and 1xbet online sports betting viability in a growing tissue. Dev Biol. 2023 Sep;501:1-19. doi: 10.1016/j.ydbio.2023.05.006. PMID: 37269969.
Messer CL, 1xbet online sports betting . 2023. Expect the unexpected: conventional and unconventional roles for cadherins in collective 1xbet online sports betting migration. Biochem Soc Trans. 2023 Aug 31;51(4):1495-1504. doi: 10.1042/BST20221202. PMID: 37387360
Kotian N, Troike KM, Curran KN, Lathia JD, 1xbet online sports betting . 2022. A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective 1xbet online sports betting migration. G3 (Bethesda). 2022 Jan 4;12(1):jkab356. doi: 10.1093/g3journal/jkab356. PMID: 34849760
Chen Y, Kotian N, Aranjuez G, Chen L, Messer CL, Burtscher A, Sawant K, Ramel D, Wang X, 1xbet online sports betting . 2020. Protein phosphatase 1 activity controls a balance between collective and single 1xbet online sports betting modes of migration. Elife 9:e52979. doi: 10.7554/eLife.52979. PMID: 32369438.
Volovetz J, Berezovsky AD, Alban T, Chen Y, Lauko A, Aranjuez GF, Burtscher A, Shibuya K, Silver DJ, Peterson J, Manor D, 1xbet online sports betting , Lathia JD. 2020. Identifying conserved molecular targets required for 1xbet online sports betting migration of glioblastoma cancer stem cells. 1xbet online sports betting Death Dis. 11(2):152. doi: 10.1038/s41419-020-2342-2. PMID: 32102991.
View the complete publication list in NCBI